Evidence map›Paper›PMID 33003310›Full record

ArticleInternational journal of molecular sciences2020

Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae.

Abha Sahni, Hema P Narra, Sanjeev K Sahni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. ATG9 inhibitsAutophagy · 2025
    Article
  2. Infection and immunity · 2025
    Article
  3. Article
  4. Review
  5. Host-Pathogen Interaction 3.0.International journal of molecular sciences · 2022
    Article
  6. Apoptosis and Autophagy: Current Understanding in Tick-Pathogen Interactions.Frontiers in cellular and infection microbiology · 2022
    Review
  7. Mediterranean Spotted Fever: Current Knowledge and Recent Advances.Tropical medicine and infectious disease · 2021
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Abha SahniDepartment of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX 77555-0609, USA.
Hema P NarraDepartment of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX 77555-0609, USA.
Sanjeev K SahniDepartment of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX 77555-0609, USA.
The University of Texas Medical Branch at Galveston · US

Funding

Role of mTOR signaling in endothelial responses to Rickettsia rickettsii infection.R21AI144888 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SAHNI, ABHA · 2020 to 2021
$435k
Defining the roles of an enhancer long non-coding RNA eIncRNA-ID2 in rickettsial pathogenesis and immunityR21AI146681 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SAHNI, ABHA · 2021 to 2022
$435k
Institute for Human Infections and Immunity (IHII), University of Texas Medical Branch (UTMB) NoneNational Institute of Allergy and Infectious Diseases 1 R21 AI144888-01A1 and 5 R01 AI127899-03NIAID NIH HHS R21 AI144888NIAID NIH HHS R21 AI146681
6 · The paper itself

Abstract

Attributed to the tropism for host microvascular endothelium lining the blood vessels, vascular inflammation and dysfunction represent salient features of rickettsial pathogenesis, yet the details of fundamentally important pathogen interactions with host endothelial cells (ECs) as the primary targets of infection remain poorly appreciated. Mechanistic target of rapamycin (mTOR), a serine/threonine protein kinase of the phosphatidylinositol kinase-related kinase family, assembles into two functionally distinct complexes, namely mTORC1 (Raptor) and mTORC2 (Rictor), implicated in the determination of innate immune responses to intracellular pathogens via transcriptional regulation. In the present study, we investigated activation status of mTOR and its potential contributions to host EC responses during

Indexed as

Endothelial CellsEndotheliumHumansImmunity, InnateMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2PhosphorylationProto-Oncogene Proteins c-aktRibosomal Protein S6 Kinases, 70-kDaRickettsiaceaeSignal TransductionSpotted Fever Group RickettsiosisTOR Serine-Threonine KinasesTranscription, GeneticAKT1 protein, humanMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MTOR protein, humanProto-Oncogene Proteins c-aktRibosomal Protein S6 Kinases, 70-kDaTOR Serine-Threonine KinasesAkt (protein kinase B)endothelial cellsmTORprotein kinase CRickettsia

Identifiers

PMID33003310
PMCPMC7582468
OpenAlexW3088328157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.