ArticleEuropean journal of dentistry2021
Curcumin Promotes Collagen Type I, Keratinocyte Growth Factor-1, and Epidermal Growth Factor Receptor Expressions in the In Vitro Wound Healing Model of Human Gingival Fibroblasts.
Article in European journal of dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05147376 (Effectiveness of a Curcumin Mouthwash in Preventing Traumatic Ulcers in Patients With Fixed Orthodontic Appliances), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Curcumin Mouthwash in Preventing Traumatic Ulcers in Patients With Fixed Orthodontic Appliances: a Randomized Clinical Trial
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Pooled it
- The potential application of natural products in cutaneous wound healing: A review of preclinical evidence.Frontiers in pharmacology · 2022Pooled it
- Effectiveness of curcumin mouthwash in preventing traumatic ulcers in orthodontic patients.BMC oral health · 2025Trial
- Efficacy and Safety of an Oral Low-Dose Water-Dispersible Turmeric Extract Capsule on Facial Skin Health in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Trial.Journal of cosmetic dermatology · 2025Trial
- Nanocurcumin-containing Spongy Membrane for Improving the Quality of Hard and Soft Tissues in the Extracted Tooth Area: A Double-Blind Split-Mouth Clinical Trial Study.Pharmaceutical nanotechnology · 2025Trial
- Green-SynthesizedJournal of functional biomaterials · 2026Article
- Distinct Molecular Mechanisms in Oral Mucosal Wound Healing: Translational Insights and Future Directions.International journal of molecular sciences · 2025Review
- Optimizing wound healing: insights from phytochemicals and advanced therapies.Inflammopharmacology · 2025Review
- Evaluation of decellularized caprine small intestine submucosa encapsulated with nano-formulations of cerium oxide and curcumin in the management of burn wound.Regenerative therapy · 2024Article
- Potential of Curcumin in the Management of Skin Diseases.International journal of molecular sciences · 2024Review
- Food Safety Assessment and Nutraceutical Outcomes of Dairy By-Products: Ovine Milk Whey as Wound Repair Enhancer on Injured Human Primary Gingival Fibroblasts.Foods (Basel, Switzerland) · 2024Article
- Article
- Effects of Chrysin on Oral Squamous Cell Carcinoma In Vitro.European journal of dentistry · 2023Article
- Hydrogel-Based Biomaterial as a Scaffold for Gingival Regeneration: A Systematic Review of In Vitro Studies.Polymers · 2023Review
- The Efficacy of Curcumin Patch as an Adjuvant Therapeutic Agent in Managing Acute Orofacial Pain on the Post-Cleft Lip and Cleft Palate Surgery Patients: A Pragmatic Trial.European journal of dentistry · 2023Article
- Ultrastructural and Physicochemical Characterization of a Non-Crosslinked Type 1 Bovine Derived Collagen Membrane.Polymers · 2021Article
- Curcumin upregulates transforming growth factor-β1, its receptors, and vascular endothelial growth factor expressions in an in vitro human gingival fibroblast wound healing model.BMC oral health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveCurcumin promotes oral wound healing; however, the underlying mechanism remains unknown. We hypothesized that curcumin may regulate gene expression in human gingival fibroblasts (hGFs). This study investigated the effect of curcumin on the expression of wound healing-related genes, collagen type I (COL1), keratinocyte growth factor (KGF)-1, and epidermal growth factor receptor (EGFR), in the MATERIALS AND
methodsThe hGFs were treated with curcumin in the unwounded condition and in the STATISTICAL ANALYSIS: Data were analyzed by independent
resultsIn unwounded hGFs, curcumin significantly increased KGF-1 and EGFR expressions but not COL1 mRNA expression. Interestingly, curcumin significantly upregulated COL1, KGF-1, and EGFR expressions in the
conclusionCurcumin induced KGF-1 and EGFR expressions in unwounded hGFs. In the
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.