Evidence map›Paper›PMID 33002514›Full record

ReviewThe Journal of allergy and clinical immunology2020

Pediatric recurrent fever and autoinflammation from the perspective of an allergist/immunologist.

Lori Broderick, Hal M Hoffman

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lori BroderickDivision of Allergy, Immunology & Rheumatology, Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, Calif. Electronic address: lbroderick@ucsd.edu.
Hal M HoffmanDivision of Allergy, Immunology & Rheumatology, Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, Calif.
University of California San Diego · US

Funding

Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki DiseaseR01HL140898 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURNS, JANE C, HOFFMAN, HAROLD M · 2018 to 2022
$4.3M
The Neutrophil Lineage in InflammasomopathiesR01AI155869 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CROKER, BEN ADAM, HOFFMAN, HAROLD M · 2020 to 2024
$2.0M
Molecular Genetics and Immunoregulatory mechanisms of PFAPA syndromeK08HD075830 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRODERICK, LORI · 2014 to 2018
$769k
NHLBI NIH HHS R01 HL140898NIAID NIH HHS R01 AI155869NICHD NIH HHS K08 HD075830
6 · The paper itself

Abstract

Autoinflammatory diseases are monogenic and polygenic disorders due to dysregulation of the innate immune system. The inherited conditions have been clustered with primary immunodeficiencies in the latest practice parameters; however, these diseases have unique clinical presentations, genetics, and available therapies. Given the presentation of fevers, rashes, and mucosal symptoms observed in many of these syndromes, patients are likely to present to an allergist/immunologist. Although there has been attention in the literature to diagnosis and treatment of rare, genetically defined autoinflammatory disorders, physicians are challenged by increasing numbers of patients with intermittent or periodic fevers who face unnecessary morbidities due to a lack of a diagnosis. The broad differential of diseases presenting with fever includes autoinflammatory syndromes, infections associated with immunodeficiency and/or allergies complicated by infection, and less commonly, autoimmune disorders or malignancy. To address this challenge, we review the history of the medical approach to fever, current diagnostic paradigms, and controversies in management. We describe the spectrum of disorders referred to a recurrent fever disorders clinic established in an Allergy/Immunology division at a tertiary pediatric care center. Finally, we provide practical recommendations including historical features and initial laboratory investigations that can help clinicians appropriately manage these patients.

Indexed as

Allergy and ImmunologyAllergistsAutoimmune DiseasesChildDiagnosis, DifferentialHereditary Autoinflammatory DiseasesHumansImmunologic Deficiency SyndromesInflammationTertiary Care CentersautoinflammationPediatricsperiodic feverrecurrent fever

Identifiers

PMID33002514
PMCPMC8559310
OpenAlexW3090574324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.