ArticleDevelopmental cell2020
Combinatorial Action of Temporally Segregated Transcription Factors.
Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- HERMES: an open-source mining tool for open-access literature.Bioinformatics advances · 2026Article
- Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus.Nature structural & molecular biology · 2025Article
- Combinatorial transcription factor binding encodes cis-regulatory wiring of mouse forebrain GABAergic neurogenesis.Developmental cell · 2025Article
- Detecting gene expression in Caenorhabditis elegans.Genetics · 2025Review
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Recent advances in understanding microRNA function and regulation in C. elegans.Seminars in cell & developmental biology · 2024Review
- Article
- Transcription factor condensates and signaling driven transcription.Nucleus (Austin, Tex.) · 2023Review
- What is an enhancer?BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- High-throughput functional characterization of combinations of transcriptional activators and repressors.Cell systems · 2023Article
- Transcript accumulation rates in the earlyScience advances · 2023Article
- The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes.Essays in biochemistry · 2022Article
- Spalt and disco define the dorsal-ventral neuroepithelial compartments of the developing Drosophila medulla.Genetics · 2022Article
- Hand Dissection of Caenorhabditis elegans Intestines.Journal of visualized experiments : JoVE · 2022Article
- pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo.Developmental biology · 2022Article
- Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in flies.Developmental cell · 2022Article
- Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during Caenorhabditis elegans endoderm development.Development (Cambridge, England) · 2022Article
- Emerging Roles of RNA-Binding Proteins in Neurodevelopment.Journal of developmental biology · 2022Review
- The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo.PLoS genetics · 2022Article
- A modified TurboID approach identifies tissue-specific centriolar components in C. elegans.PLoS genetics · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Combinatorial action of transcription factors (TFs) with partially overlapping expression is a widespread strategy to generate novel gene-expression patterns and, thus, cellular diversity. Known mechanisms underlying combinatorial activity require co-expression of TFs within the same cell. Here, we describe the mechanism by which two TFs that are never co-expressed generate a new, intersectional expression pattern in C. elegans embryos: lineage-specific priming of a gene by a transiently expressed TF generates a unique intersection with a second TF acting on the same gene four cell divisions later; the second TF is expressed in multiple cells but only activates transcription in those where priming occurred. Early induction of active transcription is necessary and sufficient to establish a competent state, maintained by broadly expressed regulators in the absence of the initial trigger. We uncover additional cells diversified through this mechanism. Our findings define a mechanism for combinatorial TF activity with important implications for generation of cell-type diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.