Evidence map›Paper›PMID 33002377›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2020

Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease.

Jacob C Monroe, Chen Lin, Susan M Perkins, Yan Han, Brett J Wong, Raghu L Motaganahalli, Bruno T Roseguini

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Microvascular Dysfunction in Peripheral Artery Disease: Is Heat Therapy a Viable Treatment?International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jacob C MonroeDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana.
Chen LinDepartment of Radiology, Mayo Clinic, Jacksonville, Florida.
Susan M PerkinsDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana.
Yan HanDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana.
Brett J WongDepartment of Kinesiology and Health, Georgia State University, Atlanta, Georgia.ORCID 0000-0002-4763-0208
Raghu L MotaganahalliDivision of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Bruno T RoseguiniDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana.
Indiana University School of MedicinePurdue University West Lafayette · USGeorgia State University · USJacksonville College · US

Funding

Heat therapy for Intermittent ClaudicationR21AG053687 · NIA · PURDUE UNIVERSITY · PI ROSEGUINI, BRUNO T · 2018 to 2019
$434k
American Heart Association-American Stroke Association 16SDH27600003NIA NIH HHS 1R21AG053687-01A1NIA NIH HHS R21 AG053687
6 · The paper itself

Abstract

A single session of leg heat therapy (HT) has been shown to elicit increases in leg blood flow and reduce blood pressure (BP) and the circulating levels of endothelin-1 (ET-1) in patients with symptomatic peripheral artery disease (PAD). We assessed whether 6 wk of supervised leg HT (3 times/wk) with water-circulating trousers perfused with water at 48°C improved 6-min walk distance in individuals with PAD compared with a sham treatment. Secondary outcomes included the assessment of leg vascular function, BP, quality of life, and serum ET-1 and nitrite plus nitrate (NOx) levels. Of 32 PAD patients randomized, 30 [age: 68 ± 8 yr; ankle-brachial index (ABI): 0.6 ± 0.1] completed the 3- and 6-wk follow-ups. Participants completed 98.7% of the treatment sessions. Compared with the sham treatment, exposure to HT did not improve 6-min walk distance, BP, popliteal artery reactive hyperemia, cutaneous microvascular reactivity, resting ABI, or serum NOx levels. The change from baseline to 6 wk in scores of the physical functioning subscale of the 36-item Short Form Health Survey was significantly higher in the HT group (control -6.9 ± 10 vs. HT 6.8 ± 15; 95% confidence interval: 2.5-24.3,

Indexed as

Peripheral Arterial DiseaseWalkingAgedHot TemperatureHumansIntermittent ClaudicationLegMiddle AgedQuality of Lifeendothelin-1heat therapyintermittent claudicationperipheral artery diseasequality of life

Identifiers

PMID33002377
PMCPMC7792848
OpenAlexW3089542900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.