Evidence map›Paper›PMID 33002202›Full record

ArticleJournal of surgical oncology2021

A novel preoperative risk score to optimize patient selection for performing concomitant liver resection with cytoreductive surgery/HIPEC.

Rachel M Lee, Adriana C Gamboa, Michael K Turgeon, Mohammad Y Zaidi, Charles Kimbrough, Jennifer Leiting, Travis Grotz, Andrew J Lee, Keith Fournier, Benjamin Powers and 19 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 1 institution in 1 country.

Rachel M LeeDepartment of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Adriana C GamboaDepartment of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Michael K TurgeonDepartment of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Mohammad Y ZaidiDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Charles KimbroughDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Jennifer LeitingDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-5784-7937
Travis GrotzDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-7753-097X
Andrew J LeeDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Keith FournierDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Benjamin PowersDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-2679-6302
Sean DineenDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Joel M BaumgartnerDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Jula VeerapongDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Harveshp MogalDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-5743-1424
Callisia ClarkeDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-5229-961X
Gregory WilsonDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Sameer PatelDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-6442-1857
Ryan HendrixDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-2176-4283
Laura LambertDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Courtney PokrzywaDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Daniel E AbbottDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Christopher J LaRoccaDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Mustafa RaoofDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-4710-2226
Jonathan GreerDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Fabian M JohnstonDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Charles A StaleyDepartment of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Jordan M CloydDepartment of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Shishir K MaithelDepartment of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Maria C RussellDepartment of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
University of Minnesota · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
J: NRSA Training CoreTL1TR002382 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Vasiliki Michopoulos · 2017 to 2026
$8.5M
NCATS NIH HHS TL1 TR002382NCATS NIH HHS UL1 TR002378
6 · The paper itself

Abstract

backgroundWhile parenchymal hepatic metastases were previously considered a contraindication to cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), liver resection (LR) is increasingly performed with CRS/HIPEC.

methodsPatients from the US HIPEC Collaborative (2000-2017) with invasive appendiceal or colorectal adenocarcinoma undergoing primary, curative intent CRS/HIPEC with CC0-1 resection were included. LR was defined as a formal parenchymal resection. Primary endpoints were postoperative complications and overall survival (OS).

resultsA total of 658 patients were included. About 83 (15%) underwent LR of colorectal (58%) or invasive appendiceal (42%) metastases. LR patients had more complications (81% vs. 60%; p = .001), greater number of complications (2.3 vs. 1.5; p < .001) per patient and required more reoperations (22% vs. 11%; p = .007) and readmissions (39% vs. 25%; p = .014) than non-LR patients. LR patients had decreased OS (2-year OS 62% vs. 79%, p < .001), even when accounting for peritoneal carcinomatosis index and histology type. Preoperative factors associated with decreased OS on multivariable analysis in LR patients included age < 60 years (HR, 3.61; 95% CI, 1.10-11.81), colorectal histology (HR, 3.84; 95% CI, 1.69-12.65), and multiple liver tumors (HR, 3.45; 95% CI, 1.21-9.85) (all p < .05). When assigning one point for each factor, there was an incremental decrease in 2-year survival as the risk score increased from 0 to 3 (0: 100%; 1: 91%; 2: 58%; 3: 0%).

conclusionsAs CRS/HIPEC + LR has become more common, we created a simple risk score to stratify patients considered for CRS/HIPEC + LR. These data aid in striking the balance between an increased perioperative complication profile with the potential for improvement in OS.

Indexed as

Patient SelectionAppendiceal NeoplasmsChemotherapy, Cancer, Regional PerfusionColorectal NeoplasmsCombined Modality TherapyCytoreduction Surgical ProceduresFemaleFollow-Up StudiesHepatectomyHumansHyperthermia, InducedMaleMiddle AgedPeritoneal NeoplasmsPreoperative CarePrognosisappendiceal adenocarcinomacolorectal cancerHIPECliver resectionrisk score

Identifiers

PMID33002202
PMCPMC7957345
OpenAlexW3089447903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.