ArticlePLoS pathogens2020
Sclerotinia sclerotiorum utilizes host-derived copper for ROS detoxification and infection.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Copper Compounds: A Narrative and Regulatory Review of Agricultural Uses, Risks, and Environmental Assessment.Toxics · 2026Review
- A TaSnRK1α-TaCAT2 model mediates resistance to Fusarium crown rot by scavenging ROS in common wheat.Nature communications · 2025Article
- Fusiform nanoparticle boosts efficient genetic transformation in Sclerotinia sclerotiorum.Journal of nanobiotechnology · 2024Article
- Inhibition of Monilinia fructicola sporulation and pathogenicity through eucalyptol-mediated targeting of MfCat2 by Streptomyces lincolnensis strain JCP1-7.Molecular plant pathology · 2024Article
- An effector SsCVNH promotes the virulence of Sclerotinia sclerotiorum through targeting class III peroxidase AtPRX71.Molecular plant pathology · 2024Article
- Comparative transcriptome analysis in two contrasting genotypes for Sclerotinia sclerotiorum resistance in sunflower.PloS one · 2024Article
- Comparative transcriptome analysis of resistant and susceptible watermelon genotypes reveals the role of RNAi, callose, proteinase, and cell wall in squash vein yellowing virus resistance.Frontiers in plant science · 2024Article
- Knockout of transcription factor OsERF65 enhances ROS scavenging ability and confers resistance to rice sheath blight.Molecular plant pathology · 2023Article
- A First Report ofPlants (Basel, Switzerland) · 2023Article
- Screening of microRNAs and target genes involved in Sclerotinia sclerotiorum (Lib.) infection in Brassica napus L.BMC plant biology · 2023Article
- QTL mapping and transcriptome analysis identify novel QTLs and candidate genes in Brassica villosa for quantitative resistance against Sclerotinia sclerotiorum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Comparative transcriptome profiling reveals the importance ofFrontiers in microbiology · 2023Article
- Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi.Nature communications · 2022Article
- Transcription factor SsFoxE3 activating SsAtg8 is critical for sclerotia, compound appressoria formation, and pathogenicity in Sclerotinia sclerotiorum.Molecular plant pathology · 2022Article
- HighFrontiers in plant science · 2022Article
- Genome-Wide Identification of Rapid Alkalinization Factor Family inFrontiers in plant science · 2022Article
- Sclerotinia sclerotiorum Thioredoxin1 (SsTrx1) is required for pathogenicity and oxidative stress tolerance.Molecular plant pathology · 2021Article
- Exploring the Symbiotic Mechanism of a Virus-Mediated Endophytic Fungus in Its Host by Dual Unique Molecular Identifier-RNA Sequencing.mSystems · 2021Article
- Analysis of differentially expressed Sclerotinia sclerotiorum genes during the interaction with moderately resistant and highly susceptible chickpea lines.BMC genomics · 2021Article
- Transcriptome Analysis Reveals the Complex Molecular Mechanisms ofFrontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotrophic plant pathogen induces host reactive oxygen species (ROS) production, which leads to necrosis in the host, allowing the pathogen to absorb nutrients from the dead tissues. Sclerotinia sclerotiorum is a typical necrotrophic pathogen that causes Sclerotinia stem rot in more than 400 species, resulting in serious economic losses. Here, we found that three S. sclerotiorum genes involved in copper ion import/transport, SsCTR1, SsCCS and SsATX1, were significantly up-regulated during infection of Brassica oleracea. Function analysis revealed that these genes involved in fungal ROS detoxification and virulence. On the host side, four genes putatively involved in copper ion homeostasis, BolCCS, BolCCH, BolMT2A and BolDRT112, were significantly down-regulated in susceptible B. oleracea, but stably expressed in resistant B. oleracea during infection. Their homologs were found to promote resistance to S. sclerotiorum and increase antioxidant activity in Arabidopsis thaliana. Furthermore, copper concentration analysis indicated that copper flow from healthy area into the necrotic area during infection. A model was proposed that S. sclerotiorum utilizes host copper to detoxify ROS in its cells, whereas the resistant hosts may restrict the supply of essential copper nutrients to S. sclerotiorum by maintaining copper ion homeostasis during infection.
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