ArticlePloS one2020
Forgetting to take antiseizure medications is associated with focal to bilateral tonic-clonic seizures, as revealed by a cross-sectional study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Factors Associated With Antiseizure Medication Adherence in Patients With Epilepsy: A Systematic Review.Brain and behavior · 2026Pooled it
- Does Missing Medication Acutely Change Seizure Risk? A Prospective Study.Annals of neurology · 2026Article
- Facilitators and barriers of antiseizure medication adherence from Australian healthcare providers' perspectives: A qualitative study.Epilepsia open · 2025Article
- Multicentric study of adherence to antiseizure medications among adults with epilepsy attended in neurology departments in Burkina Faso.Epilepsia open · 2025Article
- Barriers to Medication Adherence in People Living With Epilepsy.Neurology. Clinical practice · 2025Article
- The seizure severity score: a quantitative tool for comparing seizures and their response to therapy.Journal of neural engineering · 2023Article
- Detecting Reasons for Nonadherence to Medication in Adults with Epilepsy: A Review of Self-Report Measures and Key Predictors.Journal of clinical medicine · 2022Review
- Current Status and Future Objectives of Surgical Therapies for Epilepsy in Japan.Neurologia medico-chirurgica · 2021Article
- Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements.BMC neurology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the effects of nonadherence to antiseizure medications (ASMs) and clinical characteristics on seizure control, we employed a prospective cohort cross-sectional study using self-reports and medical records of patients with epilepsy (PWEs).
methodsEight hundred and fifty-five PWEs taking ASMs were enrolled from fourteen collaborative outpatient clinics from January 2018 to March 2019. Questions from the Morisky Medication Adherence Scale were used as adherence self-reports. If a PWE's questionnaire indicated that they had missed doses of their ASMs, outpatient physicians asked them directly about the details of their compliance, including the timing of intentionally or unintentionally missed doses. The association between lack of seizure control and utilization outcomes, such as missed doses, demographics, and clinical characteristics of the PWEs, were assessed by univariate and multivariate analyses.
resultsMultivariate analysis revealed that forgetting to take ASMs was associated with lack of seizure control and the existence of focal to bilateral tonic-clonic seizures. Dementia, younger age, use of three or more antiepileptic agents, and living in a one-person household were associated with the risk of forgetting to take ASMs. SIGNIFICANCE: For PWEs with poor drug management or a high incidence of missed doses of ASMs, efforts to improve adherence could facilitate better seizure control and decrease focal to bilateral tonic-clonic propagation.
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