ArticlePLoS neglected tropical diseases2020
High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- A LAMP-based assay for rapid detection of human scabies using clinical skin scraping specimens.Scientific reports · 2026Article
- Genome-wide host-associated population structure ofScience in One Health · 2026Article
- Over-expression and increased copy numbers of a cytochrome P450 and two UDP-glucuronosyltransferase genes in macrocyclic lactone resistant Psoroptes ovis of cattle.PLoS pathogens · 2025Article
- Scabies.Nature reviews. Disease primers · 2024Review
- Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife.International journal for parasitology. Drugs and drug resistance · 2023Review
- Draft genome sequencing data of a feather mite,Data in brief · 2023Article
- Assembly of a Draft Genome for the Mouse EctoparasiteJournal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Investigating the Antibacterial Properties of Prospective Scabicides.Biomedicines · 2022Article
- Proteomic analysis of Sarcoptes scabiei reveals that proteins differentially expressed between eggs and female adult stages are involved predominantly in genetic information processing, metabolism and/or host-parasite interactions.PLoS neglected tropical diseases · 2022Article
- Effects ofInternational journal of molecular sciences · 2022Article
- Evidence that Transcriptional Alterations inInternational journal of molecular sciences · 2022Article
- Chromosome-scale Echinococcus granulosus (genotype G1) genome reveals the Eg95 gene family and conservation of the EG95-vaccine molecule.Communications biology · 2022Article
- Assessing species coverage and assembly quality of rapidly accumulating sequenced genomes.GigaScience · 2022Article
- Laboratory-based diagnosis of scabies: a review of the current status.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Review
- An RNA Interference Tool to Silence Genes inInternational journal of molecular sciences · 2022Article
- Transcriptome Analysis ofFrontiers in microbiology · 2022Article
- Immunomodulatory effects of two recombinant arginine kinases inFrontiers in immunology · 2022Article
- Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the Sarcoptes scabiei genome.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.