ArticleDepression and anxiety2021
Neurophysiological markers of response to theta burst stimulation in youth depression.
Article in Depression and anxiety, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Critical role of rhythms in prefrontal transcranial magnetic stimulation for depression: A randomized sham-controlled study.Human brain mapping · 2022Trial
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Neurodevelopmental considerations for transcranial magnetic stimulation trials in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Unveiling Major Depressive Disorder Through TMS-EEG: From Traditional to Emerging Approaches.Biomedicines · 2025Review
- Assessing Neuromodulation Effects of Theta Burst Stimulation to the Prefrontal Cortex Using Transcranial Magnetic Stimulation Electroencephalography (TMS-EEG).The European journal of neuroscience · 2025Article
- Influence of Large-Scale Brain State Dynamics on the Evoked Response to Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Transcranial Magnetic Stimulation Across the Lifespan: Impact of Developmental and Degenerative Processes.Biological psychiatry · 2024Review
- Baseline markers of cortical excitation and inhibition predict response to theta burst stimulation treatment for youth depression.Scientific reports · 2023Article
- A naturalistic study comparing the efficacy of unilateral and bilateral sequential theta burst stimulation in treating major depression - the U-B-D study protocol.BMC psychiatry · 2023Article
- Using TMS-EEG to assess the effects of neuromodulation techniques: a narrative review.Frontiers in human neuroscience · 2023Review
- Changes in the TMS-evoked potential N100 in the dorsolateral prefrontal cortex as a function of depression severity in adolescents.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundTheta burst stimulation (TBS) has recently been proposed as a novel treatment for youth depression. However, the impact of TBS on the youth brain and neurophysiological predictors of response to TBS in this population have not been investigated.
methodsCortical reactivity was assessed at baseline and following 2 weeks of bilateral dorsolateral prefrontal cortex (DLPFC) TBS treatment in 16 youth with depression (aged 16-24 years old). In 16 age-matched health youths, cortical reactivity was assessed twice, 2 weeks apart. Transcranial magnetic stimulation (TMS) combined with electroencephalography was used to assess TMS-evoked potentials in bilateral DLPFC, motor cortices, and intraparietal lobules (IPL). Resting-state functional magnetic resonance imaging (fMRI) data was also collected at baseline.
resultsLeft DLPFC pretreatment cortical reactivity, specifically the negativity at 45 ms (i.e., N45), which is related to GABA
conclusionsTMS-probed cortical inhibition at the site of TBS application may have potential as a predictor of treatment response in youth depression. Furthermore, pre-treatment functional connectivity may predict the impact of TBS on the neurophysiology of regions distal to the stimulation site. Collectively, these results offer novel neurophysiological insights into the application of TBS for youth depression, which may facilitate its wider use in the youth population.
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