Evidence map›Paper›PMID 33001399›Full record

ArticleNeurotoxicity research2020

Lipopolysaccharide-Elicited Systemic Inflammation Induces Selective Vulnerability of Cerebral Cortex and Striatum of Developing Glutaryl-CoA Dehydrogenase Deficient (Gcdh

Bianca Seminotti, Alexandre Umpierrez Amaral, Mateus Grings, César Augusto João Ribeiro, Guilhian Leipnitz, Moacir Wajner

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  5. Less Severe Polymicrobial Sepsis in ConditionalInternational journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bianca SeminottiPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Building 21111, Porto Alegre, RS, 90035-003, Brazil. bianca.seminotti@ufrgs.br.ORCID https://orcid.org/0000-0002-9803-7746
Alexandre Umpierrez AmaralPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Building 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID https://orcid.org/0000-0001-6512-0714
Mateus GringsPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Building 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID https://orcid.org/0000-0002-2439-3350
César Augusto João RibeiroNatural and Humanities Sciences Center, Universidade Federal do ABC, São Bernardo do Campo, SP, 09606-070, Brazil.ORCID https://orcid.org/0000-0003-4604-9945
Guilhian LeipnitzPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Building 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID https://orcid.org/0000-0001-7964-8923
Moacir WajnerPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Building 21111, Porto Alegre, RS, 90035-003, Brazil.ORCID https://orcid.org/0000-0001-6372-1807
Universidade Federal do Rio Grande do Sul · BRUniversidade Federal do ABC · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 425914/2016-0Financiadora de Estudos e Projetos 01.06.0842-00Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 2266-2551/14-2Hospital de Clínicas de Porto Alegre 120420Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção 573677/2008-5
6 · The paper itself

Abstract

We investigated redox homeostasis in cerebral and peripheral tissues of wild type (WT) and glutaryl-CoA dehydrogenase knockout mice (Gcdh

Indexed as

AnimalsCerebral CortexCorpus StriatumDose-Response Relationship, DrugFemaleGlutaryl-CoA DehydrogenaseInflammation MediatorsLipopolysaccharidesMaleMiceMice, 129 StrainMice, KnockoutOxidative StressGlutaryl-CoA DehydrogenaseInflammation MediatorsLipopolysaccharidesCerebral cortexGlutaric acidemia type ILipopolysaccharideOxidative stressStriatumSystemic inflammation

Identifiers

PMID33001399
OpenAlexW3089357765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.