Evidence map›Paper›PMID 33001357›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2021

LncRNA ZNF503-AS1 acts as a tumor suppressor in bladder cancer by up-regulating Ca

Haiqing He, Shuiqing Wu, Kai Ai, Ran Xu, Zhaohui Zhong, Yinhuai Wang, Lei Zhang, Xiaokun Zhao, Xuan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular oncology (Dordrecht, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Haiqing HeDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China.
Shuiqing WuDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China.
Kai AiDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China.
Ran XuDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China.
Zhaohui ZhongDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China.
Yinhuai WangDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China.
Lei ZhangDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China.
Xiaokun ZhaoDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China. xiaokunzhao@csu.edu.cn.
Xuan ZhuDepartment of Urology, The Second Xiangya Hospital, Central South University, No.139 Renmin Road, Changsha, 410011, Hunan Province, People's Republic of China. zhuxuan@csu.edu.cn.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCa

methodsDifferentially expressed long non-coding RNAs (lncRNAs) related to bladder cancer were identified using microarray analysis, followed by the verification of transcription factors to which they bind. The relationship between ZNF503-AS1, GATA6 and SLC8A1 was assessed using dual luciferase reporter, RIP and ChIP assays. The expression levels of ZNF503-AS1, GATA6 and SLC8A1 were modulated to examine their effects on the tumorigenic potential, intracellular Ca

resultsMicroarray-based expression profile analysis of the GEO GSE61615 dataset revealed that the expression of ZNF503-AS1 was decreased in bladder cancer. Subsequently, we found that ZNF503-AS1 can bind to the transcription factor GATA6 to up-regulate the expression of SLC8A1. ZNF503-AS1 and SLC8A1 were found to be down-regulated in both primary bladder cancer tissues and cells. Exogenous overexpression of ZNF503-AS1 or SLC8A1 attenuated bladder cancer cell proliferation, invasion and migration, but promoted their apoptosis, accompanied by decreased Ca

conclusionZNF503-AS1 can recruit transcription factor GATA6 to up-regulate SLC8A1 expression, thereby increasing the intracellular Ca

Indexed as

Genes, Tumor SuppressorAnimalsApoptosisCalciumCell Line, TumorCell MovementCell ProliferationDown-RegulationGATA6 Transcription FactorGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudeModels, BiologicalNeoplasm InvasivenessCalciumGATA6 Transcription Factorlong non-coding RNA ZNF503-AS1, humanRNA, Long NoncodingSodium-Calcium Exchangersodium-calcium exchanger 1Bladder cancerCa2+ concentrationGATA6Invasion and migrationLncRNAProliferationSLC8A1Transcription factorZNF503-AS1

Identifiers

PMID33001357
PMCPMC12980666
OpenAlexW3091224180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.