Evidence map›Paper›PMID 33001220›Full record

ArticleNeuroradiology2021

Acute disseminated encephalomyelitis in a COVID-19 pediatric patient.

Adélia Maria de Miranda Henriques-Souza, Ana Cláudia Marques Gouveia de Melo, Bianca de Aguiar Coelho Silva Madeiro, Leonardo Furtado Freitas, Pedro Augusto Sampaio Rocha-Filho, Fabrício Guimarães Gonçalves

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 8 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 8 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  6. COVID-19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta-analysis of the relationship to CSF SARS-CoV-2.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
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  20. Neurologic manifestations in children with COVID-19 from a tertiary center in Turkey and literature review.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Adélia Maria de Miranda Henriques-SouzaHospital da Restauração, Recife, Brazil. adelianeuro@gmail.com.ORCID https://orcid.org/0000-0002-5303-5528
Ana Cláudia Marques Gouveia de MeloHospital da Restauração, Recife, Brazil.ORCID https://orcid.org/0000-0003-1909-568X
Bianca de Aguiar Coelho Silva MadeiroHospital Universitário Oswaldo Cruz, Universidade de Pernambuco (UPE), Recife, Brazil.ORCID https://orcid.org/0000-0002-0138-8209
Leonardo Furtado FreitasHospital Beneficência Portuguesa - BP Medicina Diagnóstica, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6944-4978
Pedro Augusto Sampaio Rocha-FilhoHospital Universitário Oswaldo Cruz, Universidade de Pernambuco (UPE), Recife, Brazil.ORCID https://orcid.org/0000-0001-5725-2637
Fabrício Guimarães GonçalvesDepartment of Radiology, Division of Neuroradiology, Children's Hospital of Philadelphia, Philadelphia, 19104, PA, USA.ORCID https://orcid.org/0000-0002-8889-9879
Hospital da Restauração · BRBeneficência Portuguesa de São Paulo · BRChildren's Hospital of Philadelphia · USHospital Universitário Oswaldo Cruz · BRUniversidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The authors present a case of acute disseminated encephalomyelitis in a COVID-19 pediatric patient with positive SARS-CoV2 markers from a nasopharyngeal swab. A previously healthy 12-year-old-girl presented with a skin rash, headache, and fever. Five days after that, she had an acute, progressive, bilateral, and symmetrical motor weakness. She evolved to respiratory failure. Magnetic resonance imaging (MRI) of the brain and cervical spine showed extensive bilateral and symmetric restricted diffusion involving the subcortical and deep white matter, a focal hyperintense T2/FLAIR lesion in the splenium of the corpus callosum with restricted diffusion, and extensive cervical myelopathy involving both white and gray matter. Follow-up examinations of the brain and spine were performed 30 days after the first MRI examination. The images of the brain demonstrated mild dilatation of the lateral ventricles and widespread widening of the cerebral sulci, complete resolution of the extensive white matter restricted diffusion, and complete resolution of the restricted diffusion in the lesion of the splenium of the corpus callosum, leaving behind a small gliotic focus. The follow-up examination of the spine demonstrated nearly complete resolution of the extensive signal changes in the spinal cord, leaving behind scattered signal changes in keeping with gliosis. She evolved with partial clinical and neurological improvement and was subsequently discharged.

Indexed as

ChildCOVID-19Encephalomyelitis, Acute DisseminatedFemaleHumansMagnetic Resonance ImagingADEMBrain diseasesCentral Nervous SystemChildCOVID-19Spinal cord diseases

Identifiers

PMID33001220
PMCPMC7527786
OpenAlexW3091129639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.