ArticleInvestigative ophthalmology & visual science2020
Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Differences of the lamina cribrosa between primary open angle glaucoma and non-pathologic high myopia.International journal of ophthalmology · 2026Review
- Two-Photon Fabrication of Donor-Specific Human Lamina Cribrosa Models.Translational vision science & technology · 2025Article
- Cellular responses to short-term intraocular pressure elevation in a porcine eye explant model.Experimental eye research · 2025Article
- Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors.Journal of biomechanical engineering · 2025Article
- Association of lamina cribrosa thickness and hippocampal volume in Alzheimer's disease patients.Arquivos de neuro-psiquiatria · 2024Article
- Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia.bioRxiv : the preprint server for biology · 2024Article
- The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure.Investigative ophthalmology & visual science · 2024Article
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Morphological Changes of Glial Lamina Cribrosa of Rats Suffering from Chronic High Intraocular Pressure.Bioengineering (Basel, Switzerland) · 2022Article
- Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa.Experimental eye research · 2022Article
- HIOP-Reader: Automated Data Extraction for the Analysis of Manually Recorded Nycthemeral IOPs and Glaucoma Progression.Translational vision science & technology · 2022Article
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
- Ocular Factors of Fractal Dimension and Blood Vessel Tortuosity Derived From OCTA in a Healthy Chinese Population.Translational vision science & technology · 2022Article
- Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo.Experimental eye research · 2021Article
- Modeling the biomechanics of the lamina cribrosa microstructure in the human eye.Acta biomaterialia · 2021Article
- So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Purpose: The purpose of this study was to visualize the lamina cribrosa (LC) capillaries and collagenous beams, measure capillary tortuosity (path length over straight end-to-end length), and determine if capillary tortuosity changes when intraocular pressure (IOP) increases. Methods: Within 8 hours of sacrifice, 3 pig heads were cannulated via the external ophthalmic artery, perfused with PBS to remove blood, and then perfused with a fluorescent dye to label the capillaries. The posterior pole of each eye was mounted in a custom-made inflation chamber for control of IOP with simultaneous imaging. Capillaries and collagen beams were visualized with structured light illumination enhanced imaging at IOPs from 5 to 50 mm Hg at each 5 mm Hg increment. Capillary tortuosity was measured from the images and paired two-sample t-tests were used to assess for significant changes in relation to changes in IOP. Results: Capillaries were highly tortuous at 15 mm Hg (up to 1.45). In all but one eye, tortuosity decreased significantly as IOP increased from 15 to 25 mm Hg (P < 0.01), and tortuosity decreased significantly in every eye as IOP increased from 15 to 40 mm Hg (P < 0.01). In only 16% of capillaries, tortuosity increased with elevated IOP. Capillaries had a surprisingly different topology from the collagen beams. Conclusions: Although high capillary tortuosity is sometimes regarded as potentially problematic because it can reduce blood flow, LC capillary tortuosity may provide slack that mitigates against reduced flow and structural damage caused by excessive stretch under elevated IOP. We speculate that low capillary tortuosity could be a risk factor for damage under high IOP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.