ArticleBiology of reproduction2021
Lipid metabolism is altered in maternal, placental, and fetal tissues of ewes with small for gestational age fetuses†.
Article in Biology of reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Steroidogenic compensation and lipid deficiency with enhanced NADThe FEBS journal · 2026Article
- Doppler Ultrasound Indices and Fetal Biometry as Prenatal Markers of SGA or Non-SGA Developmental Trajectories in Naturally Nutrient-Restricted Sheep Pregnancies from Patagonia.Animals : an open access journal from MDPI · 2026Article
- Fatty acid transporters in the porcine conceptus and early placenta and the effects of polyunsaturated fatty acids on trophoblast cells.Scientific reports · 2026Article
- Maternal dietary citrulline supplementation increases fetal growth and programs pancreatic development in the lambs.Amino acids · 2026Article
- Metabolic hubs in reproduction: The regulatory network of lipid droplets in gamete and embryo physiology (Review).International journal of molecular medicine · 2026Review
- Lambs from ewes fed a poor-quality diet with realimentation exhibit increased incidence of hypothermia and divergent pre-weaning growth.Journal of animal science · 2026Article
- Metabolic, microbial, and pharmacological stimuli elicit distinct lipidomic and cytokine responses in the human placenta.Molecular human reproduction · 2026Article
- Expression Profiles of Fatty Acid Transporters and the Role of n-3 and n-6 Polyunsaturated Fatty Acids in the Porcine Endometrium.International journal of molecular sciences · 2024Article
- Single-cell RNA sequencing reveals placental response under environmental stress.Nature communications · 2024Article
- Effects of spring- versus fall-calving on perinatal nutrient availability and neonatal vigor in beef cattle.Translational animal science · 2022Article
- Article
- Maternal nutrient restriction alters thyroid hormone dynamics in placentae of sheep having small for gestational age fetuses.Domestic animal endocrinology · 2021Article
- Placental Transcriptome Adaptations to Maternal Nutrient Restriction in Sheep.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Nutrient restriction (NR) has the potential to negatively impact birthweight, an indicator of neonatal survival and lifelong health. Those fetuses are termed as small for gestational age (SGA). Interestingly, there is a spectral phenotype of fetal growth rates in response to NR associated with changes in placental development, nutrient and waste transport, and lipid metabolism. A sheep model with a maternal diet, starting at Day 35, of 100% National Research Council (NRC) nutrient requirements (n = 8) or 50% NRC (n = 28) was used to assess alterations in fetuses designated NR SGA (n = 7) or NR NonSGA (n = 7) based on fetal weight at Day 135 of pregnancy. Allantoic fluid concentrations of triglycerides were greater in NR SGA fetuses than 100% NRC and NR NonSGA fetuses at Day 70 (P < 0.05). There was a negative correlation between allantoic fluid concentrations of triglycerides (R2 = 0.207) and bile acids (R2 = 0.179) on Day 70 and fetal weight at Day 135 for NR ewes (P < 0.05). Bile acids were more abundant in maternal and fetal blood for NR SGA compared to 100% NRC and NR NonSGA ewes (P < 0.05). Maternal blood concentrations of NEFAs increased in late pregnancy in NR NonSGA compared to NR SGA ewes (P < 0.05). Protein expression of fatty acid transporter SLC27A6 localized to placentomal maternal and fetal epithelia and decreased in Day 70 NR SGA compared to 100% NRC and NR NonSGA placentomes (P < 0.05). These results identify novel factors associated with an ability of placentae and fetuses in NR NonSGA ewes to adapt to, and overcome, nutritional hardship during pregnancy.
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