Evidence map›Paper›PMID 33001031›Full record

ArticleeLife2020

Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function.

Yinan Li, Anthony Osuma, Edgar Correa, Munachiso A Okebalama, Pauline Dao, Olivia Gaylord, Jihad Aburas, Priota Islam, André Ex Brown, Paschalis Kratsios

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Article
  8. Almost 40 years of studying homeobox genes in C. elegans.Development (Cambridge, England) · 2024
    Article
  9. Review
  10. Molecular and Cellular Mechanisms of Motor Circuit Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yinan LiDepartment of Neurobiology, University of Chicago, Chicago, United States.
Anthony OsumaDepartment of Neurobiology, University of Chicago, Chicago, United States.
Edgar CorreaDepartment of Neurobiology, University of Chicago, Chicago, United States.
Munachiso A OkebalamaDepartment of Neurobiology, University of Chicago, Chicago, United States.
Pauline DaoDepartment of Neurobiology, University of Chicago, Chicago, United States.
Olivia GaylordCommittee on Development, Regeneration and Stem Cell Biology, University of Chicago, Chicago, United States.
Jihad AburasDepartment of Neurobiology, University of Chicago, Chicago, United States.
Priota IslamMRC London Institute of Medical Sciences, London, United Kingdom.
André Ex BrownMRC London Institute of Medical Sciences, London, United Kingdom.
Paschalis KratsiosDepartment of Neurobiology, University of Chicago, Chicago, United States.ORCID 0000-0002-1363-9271

Funding

Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7M
Gene regulatory mechanisms that assign and maintain motor neuron terminal differeR00NS084988 · NINDS · UNIVERSITY OF CHICAGO · PI KRATSIOS, PASCHALIS · 2016 to 2018
$739k
Identification of the transcriptional targets of three conserved regulatory factors necessary for motor neuron subtype function - Resubmission 01R21NS108505 · NINDS · UNIVERSITY OF CHICAGO · PI KRATSIOS, PASCHALIS, MILLER, DAVID M · 2019 to 2019
$442k
Medical Research Council MC-A658-5TY30NIGMS NIH HHS R25 GM109439NIGMS NIH HHS T32 GM007183NINDS NIH HHS R00 NS084988NINDS NIH HHS R21 NS108505
6 · The paper itself

Abstract

Terminal selectors are transcription factors (TFs) that establish during development and maintain throughout life post-mitotic neuronal identity. We previously showed that UNC-3/Ebf, the terminal selector of

Indexed as

Models, NeurologicalTranscription FactorsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCholinergic NeuronsHomeodomain ProteinsLarvaLocomotionMotor NeuronsNervous SystemNuclear ProteinsTime FactorsCaenorhabditis elegans ProteinsHomeodomain ProteinsNuclear ProteinsTranscription Factorsunc-30 protein, C elegansunc-3 protein, C elegansC. elegansdevelopmental biologymotor neuronsneuronal identityneurosciencetranscription factorsUNC-30/PitxUNC-3/Ebf

Identifiers

PMID33001031
PMCPMC7529460

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.