ArticleeLife2020
Dopamine promotes instrumental motivation, but reduces reward-related vigour.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- The effects of haloperidol on motor vigour and movement fusion during sequential reaching.PloS one · 2025Trial
- The effects of pramipexole on motivational vigour during a saccade task: a placebo-controlled study in healthy adults.Psychopharmacology · 2024Trial
- The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit.Acta pharmacologica Sinica · 2026Article
- Striatal Dopamine Actions and Movement: Inferences from Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Article
- Noradrenergic modulation of saccades in Parkinson's disease.Brain communications · 2024Article
- Motivational Vigor in Parkinson's Disease Requires the Short and Long Duration Response to Levodopa.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Dopamine Increases Accuracy and Lengthens Deliberation Time in Explicit Motor Skill Learning.eNeuro · 2024Article
- Dopamine regulates decision thresholds in human reinforcement learning in males.Nature communications · 2023Article
- Analysis of University Student Motivation in Cross-Border Contexts.International journal of environmental research and public health · 2023Article
- Long-Lasting Impact of Sugar Intake on Neurotrophins and Neurotransmitters from Adolescence to Young Adulthood in Rat Frontal Cortex.Molecular neurobiology · 2023Article
- Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Stress-sensitive inference of task controllability.Nature human behaviour · 2022Article
- The Cost of Imagined Actions in a Reward-Valuation Task.Brain sciences · 2022Article
- Novel insights into the effects of levodopa on the up- and downstrokes of writing sequences.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Effects of average reward rate on vigor as a function of individual variation in striatal dopamine.Psychopharmacology · 2022Article
- The effect of subliminal incentives on goal-directed eye movements.Journal of neurophysiology · 2021Article
- A mosaic of cost-benefit control over cortico-striatal circuitry.Trends in cognitive sciences · 2021Review
- Reward boosts reinforcement-based motor learning.iScience · 2021Article
- Methylphenidate boosts choices of mental labor over leisure depending on striatal dopamine synthesis capacity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may minimise opportunity cost in reward-rich environments. Competing theories propose that each type of motivation should be dependent on dopaminergic activity. We contrasted these two types of motivation with a rewarded saccade task, in patients with Parkinson's disease (PD). When PD patients were ON dopamine, they had greater response vigour (peak saccadic velocity residuals) for
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.