Evidence map›Paper›PMID 33000697›Full record

ArticleTechnology in cancer research & treatment

Comprehensive Characterization of Circular RNAs in Neuroblastoma Cell Lines.

Li Zhang, Hangyu Zhou, Jing Li, Xinyu Wang, Xin Zhang, Tieliu Shi, Guoshuang Feng

Open access · goldAbstract read
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Epigenetic Dysregulation inInternational journal of molecular sciences · 2023
    Review
  8. Article
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  12. Review
  13. Frontiers in oncology · 2022
    Article
  14. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Li ZhangBig Data and Engineering Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID 0000-0003-0665-8885
Hangyu ZhouDepartment of Clinical Laboratory, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, China.
Jing LiDepartment of Neurosurgery, Huai'an Second People's Hospital, the Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Xinyu WangBig Data and Engineering Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Xin ZhangBig Data and Engineering Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Tieliu ShiCenter for Bioinformatics and Computational Biology, and the Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.
Guoshuang FengBig Data and Engineering Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Capital Medical University · CNDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine · CNEast China Normal University · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) is a rare type of cancer but frequently occurred in children. However, it is still unclear whether circular RNAs (circRNAs) play key roles in NB tumorigenesis or progression. In this study, we identified 39,022 circRNAs across the 39 neuroblastoma and 2 normal cell lines. With the gene and circRNA expression data, we classified the NB cell lines, identified and characterized the functional circRNAs in the 3 NB classes. Specifically, 29 circRNAs were found to be dysregulated in the NB classes. Notably, 7 circRNAs located within MYCN-amplified regions were upregulated in cell lines with the high activities of MYC targets and MYCN amplification, and were highly correlated with expression of their parental gene,

Indexed as

Cell Line, TumorCell Transformation, NeoplasticEpithelial-Mesenchymal TransitionGene Regulatory NetworksHumansMAP Kinase Signaling SystemNeoplasm ProteinsNeuroblastomaN-Myc Proto-Oncogene ProteinPhosphatidylinositol 3-KinasesPrognosisProto-Oncogene Proteins c-aktrac1 GTP-Binding ProteinRNA, CircularTOR Serine-Threonine KinasesMTOR protein, humanMYCN protein, humanNBAS protein, humanNeoplasm ProteinsN-Myc Proto-Oncogene ProteinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktrac1 GTP-Binding ProteinRAC1 protein, humanRNA, CircularTOR Serine-Threonine Kinasescell linescircular RNAscompeting endogenous RNA networkepithelial mesenchymal transition (EMT)neuroblastoma (NB)

Identifiers

PMID33000697
PMCPMC7533920
OpenAlexW3089748183

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.