Evidence map›Paper›PMID 33000647›Full record

ArticleAging & mental health2021

Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA.

Dilip V Jeste, Salvatore Di Somma, Ellen E Lee, Tanya T Nguyen, Mara Scalcione, Alice Biaggi, Rebecca Daly, Jinyuan Liu, Xin Tu, Douglas Ziedonis and 3 more

Abstract read
In one paragraph

Article in Aging & mental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Family stress model pathways in middle adulthood to loneliness in later adulthood: Role of self-mastery.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2025
    Article
  2. Article
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  4. Remotely Administered Resilience- and Wisdom-Focused Intervention to Reduce Perceived Stress and Loneliness: Pilot Controlled Clinical Trial in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Article
  5. Mental health care for older adults: recent advances and new directions in clinical practice and research.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022
    Article
  6. Article
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  8. Experiencing the Unprecedented COVID-19 Lockdown: Abu Dhabi Older Adults' Challenges and Concerns.International journal of environmental research and public health · 2021
    Article
  9. The "timbre" of loneliness in later life.International psychogeriatrics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dilip V JesteDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Salvatore Di SommaDepartment of Medical-Surgery Sciences and Translational Medicine, University of Rome La Sapienza, Rome, Italy.
Ellen E LeeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Tanya T NguyenDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Mara ScalcioneGreat Network, Rome, Italy.
Alice BiaggiGreat Network, Rome, Italy.
Rebecca DalyDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Jinyuan LiuDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Xin TuDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Douglas ZiedonisDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Danielle GloriosoDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Paola AntoniniNouscom s.r.l, Rome, Italy.
David BrennerSchool of Medicine, University of California San Diego, San Diego, CA, USA.

Funding

Cognitive Consequences of Obstructive Sleep Apnea in Schizophrenia: An Investigation of Inflammatory MechanismsR01MH135147 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ellen Eun-Ok Lee · 2024 to 2026
$2.2M
Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later LifeK23MH119375 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEE, ELLEN EUN-OK · 2019 to 2023
$1.0M
Characterizing the gut microbiome in schizophrenia: Relationship to age, cognition, & disease-related factorsK23MH118435 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, TANYA T · 2019 to 2020
$375k
NIMH NIH HHS K23 MH118435NIMH NIH HHS K23 MH119375NIMH NIH HHS R01 MH135147
6 · The paper itself

Abstract

objectivesThere has been growing research interest in loneliness and wisdom in recent decades, but no cross-cultural comparisons of these constructs using standardized rating measures in older adults, especially the oldest-old. This was a cross-sectional study of loneliness and wisdom comparing middle-aged and oldest-old adults in Cilento, Italy and San Diego, United States.

methodWe examined loneliness and wisdom, using the UCLA Loneliness Scale Version 3 (UCLA-3) and San Diego Wisdom Scale (SD-WISE), respectively, in four subject groups: adults aged 50-65 and those ≥90 years from Cilento, Italy (

resultsAfter controlling for education, there were no significant group differences in levels of loneliness, while on SD-WISE the Cilento ≥90 group had lower scores compared to the other three groups. There was a strong inverse correlation between loneliness and wisdom in each of the four subject groups. Loneliness was negatively associated while wisdom was positively associated with general health, sleep quality, and happiness in most groups, with varying levels of significance.

conclusionThese results largely support cross-cultural validity of the constructs of loneliness and wisdom, and extend previous findings of strong inverse correlations between these two entities. Loneliness has become a growing public health problem, and the results of our study suggest that wisdom could be a protective factor against loneliness, although alternative explanations are also possible. Research on interventions to reduce loneliness by enhancing wisdom in older adults is needed.

Indexed as

HappinessLonelinessAgedAged, 80 and overCross-Sectional StudiesHumansItalyMiddle AgedProtective FactorsUnited Statescompassionhappinesshealthlongevitysocial isolation

Identifiers

PMID33000647
PMCPMC8012404

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.