Evidence map›Paper›PMID 33000451›Full record

ArticleMolecular neurobiology2021

L-Citrulline Level and Transporter Activity Are Altered in Experimental Models of Amyotrophic Lateral Sclerosis.

Asmita Gyawali, Shashi Gautam, Seung Jae Hyeon, Hoon Ryu, Young-Sook Kang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  3. The roles of arginases and arginine in immunity.Nature reviews. Immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Asmita Gyawali *College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, Seoul, Republic of Korea.
Shashi Gautam *College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, Seoul, Republic of Korea.
Seung Jae HyeonLaboratory for Brain Gene Regulation and Epigenetics, Center for Neuroscience, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Hoon RyuLaboratory for Brain Gene Regulation and Epigenetics, Center for Neuroscience, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Young-Sook KangCollege of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, Seoul, Republic of Korea. yskang@sm.ac.kr.ORCID http://orcid.org/0000-0002-8573-4657
Sookmyung Women's University · KRBoston University · USKorea Institute of Brain Science · KR

Funding

National Research Foundation of Korea 2019R1F1A1044048
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease caused by the death of the neurons regulating the voluntary muscles which leads to the progressive paralysis. We investigated the difference of transport function of L-citrulline in ALS disease model (NSC-34/hSOD1

Indexed as

Amino Acid Transport System y+LAmyotrophic Lateral SclerosisAnimalsAstrocytesBiological TransportCarbon RadioisotopesCell LineCitrullineDisease Models, AnimalHumansKineticsLarge Neutral Amino Acid-Transporter 1Membrane Transport ProteinsMice, TransgenicRNA, MessengerRNA, Small InterferingAmino Acid Transport System y+LCarbon-14Carbon RadioisotopesCitrullineLarge Neutral Amino Acid-Transporter 1Membrane Transport ProteinsRNA, MessengerRNA, Small InterferingSlc7a5 protein, mouseSlc7a7 protein, mouseSodiumAmyotrophic lateral sclerosis (ALS)Carrier mediated transporterLAT1 (large neutral amino acid transporter 1)L-citrullineMotor neuron diseaseNSC-34 cells

Identifiers

PMID33000451
OpenAlexW3090894754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.