Evidence map›Paper›PMID 33000446›Full record

ArticleJournal of cancer survivorship : research and practice2021

Mindfulness-based stress reduction alters brain activity for breast cancer survivors with chronic neuropathic pain: preliminary evidence from resting-state fMRI.

A M Smith, A Leeming, Z Fang, T Hatchard, O Mioduszewski, M A Schneider, A Ferdossifard, Y Shergill, E-L Khoo, P Poulin

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

A M SmithSchool of Psychology, University of Ottawa, 136 Jean-Jacques Lussier Room 2079, Ottawa, Ontario, K1N 6N5, Canada. asmith@uottawa.ca.ORCID 0000-0002-1212-2473
A LeemingSchool of Psychology, University of Ottawa, 136 Jean-Jacques Lussier Room 2079, Ottawa, Ontario, K1N 6N5, Canada.
Z FangSchool of Psychology, University of Ottawa, 136 Jean-Jacques Lussier Room 2079, Ottawa, Ontario, K1N 6N5, Canada.
T HatchardDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
O MioduszewskiSchool of Psychology, University of Ottawa, 136 Jean-Jacques Lussier Room 2079, Ottawa, Ontario, K1N 6N5, Canada.
M A SchneiderDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
A FerdossifardDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
Y ShergillThe Ottawa Health Research Institute, Ottawa, Canada.
E-L KhooThe Ottawa Health Research Institute, Ottawa, Canada.
P PoulinDepartment of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, Canada.
University of Ottawa · CAMcMaster University · CA

Funding

CIHR
6 · The paper itself

Abstract

purposeBreast cancer continues to be the most commonly diagnosed cancer among Canadian women, with as many as 25-60% of women suffering from chronic neuropathic pain (CNP) as a pervasive consequence of treatment. While pharmacological interventions have shown limited efficacy for the management of CNP to date, psychological interventions, such as mindfulness-based stress reduction (MBSR), may be a promising alterative for improving pain-related problems. The purpose of this study was to use brain imaging methods to investigate this potential.

methodsResting-state fMRI was used in female breast cancer survivors with CNP before and after an 8-week MBSR course (n = 13) and compared with a waitlist control group (n = 10).

resultsFocusing on the default mode network, the most significant results show greater posterior cingulate connectivity with medial prefrontal regions post-MBSR intervention. Moreover, this change in connectivity correlated with reduced pain severity for the MBSR group.

conclusionsThese results provide empirical evidence of a change in the brain following MBSR intervention associated with changes in the subjective experience of pain. IMPLICATIONS FOR CANCER SURVIVORS: This study gives hope for a non-invasive method of easing the struggle of CNP in women following breast cancer treatment.

Indexed as

Breast NeoplasmsCancer SurvivorsMindfulnessNeuralgiaBrainCanadaFemaleHumansMagnetic Resonance ImagingStress, PsychologicalBreast cancerChronic neuropathic painDefault mode networkMindfulness-based stress reductionOncologyResting-state fMRI

Identifiers

PMID33000446
OpenAlexW3090702099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.