Evidence map›Paper›PMID 33000366›Full record

ArticleCognitive, affective & behavioral neuroscience2020

Influence of theta-burst transcranial magnetic stimulation over the dorsolateral prefrontal cortex on emotion processing in healthy volunteers.

Ana Dumitru, Lorenzo Rocchi, Fedal Saini, John C Rothwell, Jonathan P Roiser, Anthony S David, Raphaelle M Richieri, Gemma Lewis, Glyn Lewis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cognitive, affective & behavioral neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ana DumitruDivision of Psychiatry, University College London, Maple House, 6th Floor, 149 Tottenham Court Rd, Fitzrovia, London, W1T 7BN, UK. ana.dumitru@ucl.ac.uk.
Lorenzo RocchiInstitute of Neurology, Department of Clinical and Movement Neurosciences, University College London, London, UK.
Fedal SainiInstitute of Cognitive Neuroscience, University College London, London, UK.
John C RothwellInstitute of Neurology, Department of Clinical and Movement Neurosciences, University College London, London, UK.
Jonathan P RoiserInstitute of Cognitive Neuroscience, University College London, London, UK.
Anthony S DavidDivision of Psychiatry, University College London, Maple House, 6th Floor, 149 Tottenham Court Rd, Fitzrovia, London, W1T 7BN, UK.
Raphaelle M RichieriDepartment of Psychiatry, Aix-Marseille University, Marseille, France.
Gemma LewisDivision of Psychiatry, University College London, Maple House, 6th Floor, 149 Tottenham Court Rd, Fitzrovia, London, W1T 7BN, UK.
Glyn LewisDivision of Psychiatry, University College London, Maple House, 6th Floor, 149 Tottenham Court Rd, Fitzrovia, London, W1T 7BN, UK.
University College London · GBAix-Marseille Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation is a potential treatment option for depression, with the newer intermittent theta-burst stimulation (iTBS) protocols providing brief intervention. However, their mechanism of action remains unclear. We investigated the hypothesis that iTBS influences brain circuits involved in emotion processing that are also affected by antidepressants. We predicted that iTBS would lead to changes in performance on emotion-processing tasks. We investigated the effects of intermittent TBS (iTBS) over the left dorsolateral prefrontal cortex (DLPFC) on the processing of emotional information (word recall and categorization, facial emotion recognition, and decision-making) in 28 healthy volunteers by contrasting these effects with those of sham stimulation. Each volunteer received iTBS and sham stimulation in a blinded crossover design and completed the emotion-processing tasks before and after stimulation. Compared to sham stimulation, iTBS increased positive affective processing for word recall, yet had an unexpected effect on facial emotion recognition for happy and sad faces. There was no evidence of an effect on decision-making or word categorization. We found support for our hypothesis that iTBS influences emotion processing, though some changes were not in the expected direction. These findings suggest a possible common mechanism of action between iTBS and antidepressants, and a complex neural circuitry involved in emotion processing that could potentially be tapped into via brain stimulation. Future research should investigate the neural correlates of emotion processing more closely to inform future iTBS protocols.

Indexed as

Theta RhythmTranscranial Magnetic StimulationCross-Over StudiesDouble-Blind MethodEmotionsHealthy VolunteersHumansPrefrontal CortexDorsolateral prefrontal cortex (DLPFC)Emotional processingTheta-burst stimulation (TBS)

Identifiers

PMID33000366
PMCPMC7716858
OpenAlexW3091608900

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.