Evidence map›Paper›PMID 33000355›Full record

ReviewMolecular and cellular pediatrics2020

A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney.

Ines Marek, Karl Friedrich Hilgers, Wolfgang Rascher, Joachim Woelfle, Andrea Hartner

Open access · goldAbstract readReview
In one paragraph

Review in Molecular and cellular pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  3. Missense mutation (Ser654Leu) in theBiomedical reports · 2025
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  5. Integrin Alpha8 Beta1 (81): An In-Depth Review of an Overlooked RGD-Binding Receptor.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ines MarekDepartment of Pediatrics and Adolescent Medicine, University Hospital of Erlangen, Loschgestrasse 15, 91054, Erlangen, Germany. ines.marek@uk-erlangen.de.ORCID http://orcid.org/0000-0002-6135-2531
Karl Friedrich HilgersDepartment of Nephrology and Hypertension, University Hospital of Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Wolfgang RascherDepartment of Pediatrics and Adolescent Medicine, University Hospital of Erlangen, Loschgestrasse 15, 91054, Erlangen, Germany.
Joachim WoelfleDepartment of Pediatrics and Adolescent Medicine, University Hospital of Erlangen, Loschgestrasse 15, 91054, Erlangen, Germany.
Andrea HartnerDepartment of Pediatrics and Adolescent Medicine, University Hospital of Erlangen, Loschgestrasse 15, 91054, Erlangen, Germany.
Universitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glomerulonephritis results in a dysregulation of glomerular cells and may end up in chronic alterations and subsequent loss of renal function. Therefore, understanding mechanisms, which contribute to maintain glomerular integrity, is a pivotal prerequisite for therapeutic interventions. The alpha-8 integrin chain seems to be an important player to maintain glomerular homeostasis by conferring mechanical stability and functional support for the renal capillary tuft.

Indexed as

Glomerular homeostasisGlomerulonephritisitga8Mesangial cells

Identifiers

PMID33000355
PMCPMC7527396
OpenAlexW3091091224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.