Evidence map›Paper›PMID 33000331›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Is DAT imaging abnormality in normal pressure hydrocephalus always suggestive of degeneration?

Claudia Del Gamba, Antonino Bruno, Daniela Frosini, Duccio Volterrani, Gianmichele Migaleddu, Nicola Benedetto, Paolo Perrini, Claudio Pacchetti, Mirco Cosottini, Ubaldo Bonuccelli and 1 more

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. The investigation of the gait parameter alterations in response to levodopa therapy and tap test in patients with idiopathic normal pressure hydrocephalus.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Claudia Del GambaDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Antonino BrunoDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Daniela FrosiniDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Duccio VolterraniDepartment of Translational Research and of New Surgical and Medical Technologies, Nuclear Medicine Unit, University of Pisa, Pisa, Italy.
Gianmichele MigaledduDepartment of Translational Research and of New Surgical and Medical Technologies, Neuroradiology Unit, University of Pisa, Pisa, Italy.
Nicola BenedettoDepartment of Neurosurgery, University of Pisa, Pisa, Italy.
Paolo PerriniDepartment of Neurosurgery, University of Pisa, Pisa, Italy.
Claudio PacchettiParkinson's Disease and Movement Disorders Unit, IRCCS Mondino Foundation, Pavia, Italy.
Mirco CosottiniDepartment of Translational Research and of New Surgical and Medical Technologies, Neuroradiology Unit, University of Pisa, Pisa, Italy.
Ubaldo BonuccelliDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Roberto CeravoloDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy. robertoceravolo66@gmail.com.ORCID http://orcid.org/0000-0003-1412-9406

Funding

Ministero della Salute (IT) RF- 2013-02355908
6 · The paper itself

Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is a debated entity with controversial pathogenesis, diagnostic criteria, and predictors of response after ventriculoperitoneal shunt (VPS). Parkinsonian signs are frequently reported in the clinical picture, sometimes due to the coexistence of an underlying neurodegenerative parkinsonism and sometimes in the absence thereof. To distinguish these two scenarios is crucial, since they may carry different long-term response to CSF drainage.

Indexed as

Hydrocephalus, Normal PressureParkinsonian DisordersBrainDopamine Plasma Membrane Transport ProteinsFemaleHumansSubstantia NigraTomography, Emission-Computed, Single-PhotonTropanesDopamine Plasma Membrane Transport ProteinsTropanes123I-FP-CIT-SPECTMRINormal pressure hydrocephalus (NPH)Parkinsonism

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.