ArticleJournal of the American College of Emergency Physicians open2020
Whole blood transfusion versus component therapy in trauma resuscitation: a systematic review and meta-analysis.
Article in Journal of the American College of Emergency Physicians open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- A systematic review of indications when and how a military walking blood bank could bridge blood product unavailability.Blood transfusion = Trasfusione del sangue · 2024Pooled it
- A stochastic, physiology-based digital twin model of hemostasis and oxygenation in trauma resuscitation.Research square · 2026Article
- Revisiting whole blood transfusion for the massively bleeding patient: The origins of resistance to change.Transfusion · 2026Article
- Whole blood transfusion in the management of obstetric hemorrhage: A scoping review.Transfusion · 2026Review
- Biosynthetic blood surrogates: Current status and future opportunities.Bioengineering & translational medicine · 2025Review
- Article
- Barriers and Challenges to Implementing Whole Blood Transfusion Protocols in Civilian Hospitals: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Evolution of whole blood trauma resuscitation in childbearing age females: practice patterns and trends.Trauma surgery & acute care open · 2024Article
- Volume replacement in the resuscitation of trauma patients with acute hemorrhage: an umbrella review.International journal of emergency medicine · 2023Article
- Pilot randomized controlled trial of restricted versus liberal crystalloid fluid management in pediatric post-operative and trauma patients.Pilot and feasibility studies · 2023Article
- Massive Trauma and Resuscitation Strategies.Anesthesiology clinics · 2023Review
- Resuscitation with whole blood or blood components improves survival and lessens the pathophysiological burden of trauma and haemorrhagic shock in a pre-clinical porcine model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Effects of hemodilution on coagulation function during prolonged hypotensive resuscitation in a porcine model of severe hemorrhagic shock.Trauma surgery & acute care open · 2023Article
- Management of Hemorrhagic Shock: Physiology Approach, Timing and Strategies.Journal of clinical medicine · 2022Review
- Perspective: the top 11 priorities to improve trauma outcomes, from system to patient level.Critical care (London, England) · 2022Review
- Whole blood transfusion and paroxysmal nocturnal haemoglobinuria meet again: Minor incompatibility, major trouble.Vox sanguinis · 2022Article
- Controlled Hemorrhage Sensitizes Angiotensin II-Elicited Hypertension through Activation of the Brain Renin-Angiotensin System Independently of Endoplasmic Reticulum Stress.Oxidative medicine and cellular longevity · 2022Article
- Mortality and its associated factors in transfused patients at a tertiary hospital in Uganda.PloS one · 2022Article
- Controversies and evidence gaps in the early management of severe traumatic brain injury: back to the ABCs.Trauma surgery & acute care open · 2022Review
- Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatients with hemorrhagic shock from trauma often require balanced blood product transfusion with red blood cells, plasma, and platelets. Resuscitation with whole blood resuscitation is becoming a common practice. We performed a systematic review and meta-analysis of studies comparing whole blood transfusion with balanced component therapy in patients suffering from traumatic hemorrhagic shock.
methodsWe searched MEDLINE Ovid, EMBASE, and the Cochrane Library for human studies comparing whole blood with component blood therapy published from January 2007 to June 2019. We included studies from both civilian and military settings and that reported 24-hour, in-hospital, or 30-day mortality. We followed the Preferred Reporting Items in Systematic Reviews and Meta-Analyses (PRISMA) guidelines, assessing study quality, publication bias, and heterogeneity. We used meta-analytic models to determine the associations (odds ratio [OR] with 95% confidence interval [CI]) between whole blood transfusion and (1) 24-hour mortality, and (2) in-hospital or 30-day mortality.
resultsA total of 1759 identified studies, 12 (reporting on n = 8431 patients) met inclusion criteria. There was heterogeneity in the design, setting, interventions, and outcomes of the studies. On meta-analysis, whole blood transfusion was not associated with 24-hour mortality (OR = 0.83; 95% CI = 0.56-1.24) or in-hospital/30-day mortality (OR = 0.79; 95% CI = 0.48-1.31).
conclusionIn this systematic review and meta-analysis, compared with conventional component transfusion, whole blood was not associated with 24-hour or in-hospital mortality. However, there were important limitations with and heterogeneity among the primary studies. Additional study is needed to determine the effectiveness of whole blood.
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Registered trials
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