Evidence map›Paper›PMID 32999936›Full record

ArticleACS central science2020

Pairing

Flaviana Di Lorenzo, Molly D Pither, Michela Martufi, Ilaria Scarinci, Joan Guzmán-Caldentey, Ewelina Łakomiec, Wojciech Jachymek, Sven C M Bruijns, Sonsoles Martín Santamaría, Julia-Stephanie Frick and 5 more

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 90 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Chemical science · 2026
    Article
  10. Article
  11. Article
  12. microLife · 2026
    Article
  13. Structure matters: commensalFrontiers in cellular neuroscience · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Lessons from the model gut BacteroidalesJournal of bacteriology · 2025
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 5 countries.

Flaviana Di LorenzoDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Molly D PitherDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Michela MartufiDepartment of Biology and Biotechnologies "C. Darwin", Sapienza-University of Rome, 00185 Rome, Italy.
Ilaria ScarinciDepartment of Biology and Biotechnologies "C. Darwin", Sapienza-University of Rome, 00185 Rome, Italy.
Joan Guzmán-CaldenteyDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, CIB-CSIC, 28040 Madrid, Spain.
Ewelina ŁakomiecHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław 53-114, Poland.
Wojciech JachymekHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław 53-114, Poland.
Sven C M BruijnsDepartment of Molecular Cell Biology and Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands.
Sonsoles Martín SantamaríaDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, CIB-CSIC, 28040 Madrid, Spain.
Julia-Stephanie FrickInstitute of Medical Microbiology and Hygiene, University of Tübingen, 72076 Tübingen, Germany.
Yvette van KooykDepartment of Molecular Cell Biology and Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands.
Fabrizio ChiodoDepartment of Molecular Cell Biology and Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands.
Alba SilipoDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Maria Lina BernardiniDepartment of Biology and Biotechnologies "C. Darwin", Sapienza-University of Rome, 00185 Rome, Italy.
Antonio MolinaroDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
University of Naples Federico II · ITAmsterdam University Medical Centers · NLSapienza University of Rome · ITCentro de Investigaciones Biológicas Margarita Salas · ESLudwik Hirszfeld Institute of Immunology and Experimental Therapy · PLInstitute of Medical Microbiology and Hygiene · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota guide the development of the host immune system by setting a systemic threshold for immune activation. Lipopolysaccharides (LPSs) from gut bacteria are able to trigger systemic and local proinflammatory and immunomodulatory responses, and this capability strongly relies on their fine structures. Up to now, only a few LPS structures from gut commensals have been elucidated; therefore, the molecular motifs that may be important for LPS-mammalian cell interactions at the gut level are still obscure. Here, we report on the full structure of the LPS isolated from one of the prominent species of the genus

Identifiers

PMID32999936
PMCPMC7517413
OpenAlexW3046619106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.