Evidence map›Paper›PMID 32999903›Full record

ArticleGE Portuguese journal of gastroenterology2020

Upper Endoscopy in Patients with Extra-Oesophageal Reflux Symptoms: A Multicentre Study.

Angelo Zullo, Giulia Fiorini, Gabrio Bassotti, Francesco Bachetti, Fabio Monica, Daniele Macor, Omero Alessandro Paoluzi, Giuseppe Scaccianoce, Piero Portincasa, Vincenzo De Francesco and 4 more

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GE Portuguese journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05131932 (Ablation of Esophageal Inlet Patches in Patients Referred for pH-Testing Due to Possible Extra-Esophageal Symptoms of Gastro-Esophageal Reflux Disease), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05131932 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Ablation of Esophageal Inlet Patches in Patients Referred for pH-Testing Due to Possible Extra-Esophageal Symptoms of Gastro-Esophageal Reflux Disease

TypeinterventionalSponsorAssaf-Harofeh Medical CenterRan2021 to 2024Enrolled100ConditionsGERD, Cough, MetaplasiaArmsEndoscopic ablation of inlet patch
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Angelo ZulloGastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
Giulia FioriniDepartment of Medical and Surgical Sciences, S. Orsola Hospital, University of Bologna, Bologna, Italy.
Gabrio BassottiGastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia, Italy.
Francesco BachettiGastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia, Italy.
Fabio MonicaGastroenterology and Digestive Endoscopy, Academic Hospital Cattinara, Trieste, Italy.
Daniele MacorGastroenterology and Digestive Endoscopy, Academic Hospital Cattinara, Trieste, Italy.
Omero Alessandro PaoluziGastroenterology Unit, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Giuseppe ScaccianoceInternal Medicine A. Murri, Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy.
Piero PortincasaInternal Medicine A. Murri, Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy.
Vincenzo De FrancescoSection of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
Roberto LorenzettiGastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
Ilaria Maria SaracinoDepartment of Medical and Surgical Sciences, S. Orsola Hospital, University of Bologna, Bologna, Italy.
Matteo PavoniDepartment of Medical and Surgical Sciences, S. Orsola Hospital, University of Bologna, Bologna, Italy.
Dino VairaDepartment of Medical and Surgical Sciences, S. Orsola Hospital, University of Bologna, Bologna, Italy.
University of Bologna · ITOspedale di Cattinara · ITOspedale Regina Margherita · ITUniversity of Bari Aldo Moro · ITUniversity of Perugia · ITUniversity of Foggia · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are no evidence-based recommendations for performing upper gastrointestinal endoscopy (UGIE) in patients with extra-oesophageal symptoms of gastro-oesophageal reflux disease (GORD). However, UGIEs are often performed in clinical practice in these patients. We aimed to assess the prevalence of gastro-oesophageal lesions in patients with atypical GORD symptoms.

methodsPatients complaining of at least one extra-oesophageal GORD symptom and undergoing UGIE in seven centres were prospectively enrolled. Clinically relevant lesions (Barrett's oesophagus, erosive oesophagitis, gastric precancerous conditions, peptic ulcer, cancer, and

resultsTwo hundred eleven patients were enrolled (male/female: 74/137; mean age: 55.5 ± 14.7 years). Barrett's oesophagus was detected in 4 (1.9%), erosive oesophagitis in 12 (5.7%), gastric precancerous conditions in 22 (10.4%), and

conclusionsClinically relevant lesions are uncommon among young (≤50 years) patients with extra-oesophageal GORD symptoms. Hiatal hernia is not more prevalent in patients with cardiologic symptoms and suspicion of GORD. The usefulness of UGIE in these patients is questionable.

Indexed as

Diagnostic yieldExtra-oesophageal refluxGastro-oesophageal refluxUpper gastrointestinal endoscopy

Identifiers

PMID32999903
PMCPMC7506231
OpenAlexW3005371016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.