ArticleOpen forum infectious diseases2020
Fever Patterns, Cytokine Profiles, and Outcomes in COVID-19.
Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Detection of SARS-CoV-2 in nasopharyngeal swab samples from COVID-19 patients in Riyadh, Saudi Arabia: a PCR-based study.Virology journal · 2025Article
- Identifying COVID-19 Confirmed Patients at Elevated Risk for Mortality and Need of Mechanical Ventilation Using a Novel Criteria for Hyperinflammatory Syndrome: A Retrospective Cohort, Single-center, Validation Study.Acta medica Philippina · 2025Article
- Transmission dynamics, responses, and clinical features for the first 1100 COVID-19 cases in South Batinah, Oman: Major lessons from a provincial perspective.Journal of Taibah University Medical Sciences · 2023Article
- Out-of-hospital cardiac arrest and in-hospital mortality among COVID-19 patients: A population-based retrospective cohort study.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2022Article
- Age and clinical signs as predictors of COVID-19 symptoms and cycle threshold value.The Libyan journal of medicine · 2022Article
- SARS-CoV-2 in brief: from virus to prevention.Osong public health and research perspectives · 2022Article
- Outcomes of COVID-19 Among High-Risk Individuals: A Study Comparing Febrile and Afebrile Presentation.Journal of clinical medicine research · 2022Article
- Unmasking latent extrapulmonary tuberculosis with newly diagnosed HIV-1 infection in a COVID-19 patient with prolonged fever.Oxford medical case reports · 2022Article
- The utility of remdesivir in SARS-CoV-2: A single tertiary care center experience from a developing country.Exploratory research in clinical and social pharmacy · 2022Article
- Clinical characteristics and analysis of risk factors for disease progression of patients with SARS-CoV-2 Omicron variant infection: A retrospective study of 25207 cases in a Fangcang hospital.Frontiers in cellular and infection microbiology · 2022Article
- Prevalence and Predictors of Persistent Symptoms After Clearance of SARS-CoV-2 Infection: A Multicenter Study from Egypt.Infection and drug resistance · 2022Article
- Article
- Predictors of intubation and mortality in COVID-19 patients: a retrospective study.Journal of anesthesia, analgesia and critical care · 2021Article
- Wearable sensor derived decompensation index for continuous remote monitoring of COVID-19 diagnosed patients.NPJ digital medicine · 2021Article
- A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17.Biochemical and biophysical research communications · 2021Article
- Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamers.Scientific reports · 2021Article
- Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with COVID-19.Neurobiology of stress · 2021Article
- Acute Symptoms of Mild to Moderate COVID-19 Are Highly Heterogeneous Across Individuals and Over Time.Open forum infectious diseases · 2021Article
- Characteristics of Patients Co-infected with Severe Acute Respiratory Syndrome Coronavirus 2 and Dengue Virus, Buenos Aires, Argentina, March-June 2020.Emerging infectious diseases · 2021Article
- A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation.Frontiers in cellular and infection microbiology · 2021Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlonged fever is associated with adverse outcomes in dengue viral infection. Similar fever patterns are observed in COVID-19 with unclear significance.
methodsWe conducted a hospital-based case-control study of patients admitted for COVID-19 with prolonged fever (fever >7 days) and saddleback fever (recurrence of fever, lasting <24 hours, after defervescence beyond day 7 of illness). Fever was defined as a temperature of ≥38.0°C. Cytokines were determined with multiplex microbead-based immunoassay for a subgroup of patients. Adverse outcomes were hypoxia, intensive care unit (ICU) admission, mechanical ventilation, and mortality.
resultsA total of 142 patients were included in the study; 12.7% (18/142) of cases had prolonged fever, and 9.9% (14/142) had saddleback fever. Those with prolonged fever had a median duration of fever (interquartile range [IQR]) of 10 (9-11) days for prolonged fever cases, while fever recurred at a median (IQR) of 10 (8-12) days for those with saddleback fever. Both prolonged (27.8% vs 0.9%;
conclusionsProlonged fever beyond 7 days from onset of illness can identify patients who may be at risk of adverse outcomes from COVID-19. Patients with saddleback fever appeared to have good outcomes regardless of the fever.
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