Evidence map›Paper›PMID 32999839›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain.

Jianbo Tang, Dmitry D Postnov, Kivilcim Kilic, Sefik Evren Erdener, Blaire Lee, John T Giblin, Thomas L Szabo, David A Boas

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Novel intravital approaches to quantify deep vascular structure and perfusion in the aging mouse brain using ultrasound localization microscopy (ULM).Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Renal blood flow and oxygenation.Pflugers Archiv : European journal of physiology · 2022
    Review
  12. Article
  13. Non-invasiveCell reports methods · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianbo TangNeurophotonics Center Department of Biomedical Engineering Boston University Boston MA 02215 USA.ORCID https://orcid.org/0000-0001-6532-8283
Dmitry D PostnovNeurophotonics Center Department of Biomedical Engineering Boston University Boston MA 02215 USA.
Kivilcim KilicNeurophotonics Center Department of Biomedical Engineering Boston University Boston MA 02215 USA.
Sefik Evren ErdenerNeurophotonics Center Department of Biomedical Engineering Boston University Boston MA 02215 USA.
Blaire LeeNeurophotonics Center Department of Biomedical Engineering Boston University Boston MA 02215 USA.
John T GiblinNeurophotonics Center Department of Biomedical Engineering Boston University Boston MA 02215 USA.
Thomas L SzaboNeurophotonics Center Department of Biomedical Engineering Boston University Boston MA 02215 USA.
David A BoasNeurophotonics Center Department of Biomedical Engineering Boston University Boston MA 02215 USA.

Funding

MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6M
The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneityR01NS108472 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, SCHAFFER, CHRIS B · 2018 to 2022
$3.2M
Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular ChangesR01EB021018 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2015 to 2018
$2.9M
Dual-modal ultrasound velocimetry and photoacoustic oximetry of entire rodent brain for Alzheimer's Disease studyK99AG063762 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI TANG, JIANBO · 2020 to 2020
$115k
NIA NIH HHS K99 AG063762NIBIB NIH HHS R01 EB021018NIMH NIH HHS R01 MH111359NINDS NIH HHS R01 NS108472
6 · The paper itself

Abstract

A high-speed, contrast-free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first-order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power-Doppler- and Color-Doppler-based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high-frequency noise.

Indexed as

brain imagingcerebral blood flow velocityfield autocorrelation functionfunctional ultrasound velocimetry

Identifiers

PMID32999839
PMCPMC7509671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.