Evidence map›Paper›PMID 32999768›Full record

ArticlePeerJ2020

Potential COVID-19 papain-like protease PL

Valentina L Kouznetsova, Aidan Zhang, Mahidhar Tatineni, Mark A Miller, Igor F Tsigelny

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Review
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  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Network analytics for drug repurposing in COVID-19.Briefings in bioinformatics · 2022
    Article
  13. Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  14. Strategies for drug repurposing against coronavirus targets.Current research in pharmacology and drug discovery · 2022
    Review
  15. Review
  16. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Valentina L KouznetsovaSan Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA.
Aidan ZhangREHS Program at San Diego Dupercomputer Center, University of California, San Diego, La Jolla, CA, USA.
Mahidhar TatineniSan Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA.
Mark A MillerSan Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-9590-3728
Igor F TsigelnySan Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-7155-8947
San Diego Supercomputer Center · US

Funding

Extended Development of the CIPRES Science Gateway, a Resource for Biological Research.R01GM126463 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, MARK A · 2018 to 2021
$1.9M
NIGMS NIH HHS R01 GM126463
6 · The paper itself

Abstract

Using the crystal structure of SARS-CoV-2 papain-like protease (PL

Indexed as

Computational drug designCOVID-19Drugs repurposingPapain-like protease

Identifiers

PMID32999768
PMCPMC7505060
OpenAlexW3087194367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.