Evidence map›Paper›PMID 32999480›Full record

ArticleNature2020

An enzymatic Alder-ene reaction.

Masao Ohashi, Cooper S Jamieson, Yujuan Cai, Dan Tan, Daiki Kanayama, Man-Cheng Tang, Sarah M Anthony, Jason V Chari, Joyann S Barber, Elias Picazo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Robots and Minimal, Physics-Informed Features: A Hybrid Framework for Enzyme Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. The Diels-Alder Reaction as a Key Step in Natural Product Synthesis.Progress in the chemistry of organic natural products · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. A Novel ZnMicroorganisms · 2023
    Article
  15. Natural product reports · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. In(OTf)Chemical science · 2023
    Article
  20. EnzymaticJournal of the American Chemical Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Masao Ohashi *Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Cooper S Jamieson *Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6076-6230
Yujuan Cai *State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai, China.
Dan TanDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Daiki KanayamaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Man-Cheng TangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Sarah M AnthonyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Jason V ChariDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7729-9619
Joyann S BarberDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Elias PicazoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Thomas B KakuleDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Shugeng CaoDepartment of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI, USA.
Neil K GargDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7793-2629
Jiahai ZhouState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai, China. jiahai@sioc.ac.cn.
K N HoukDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. houk@chem.ucla.edu.ORCID http://orcid.org/0000-0002-8387-5261
Yi TangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. yitang@ucla.edu.ORCID http://orcid.org/0000-0003-1597-0141

Funding

Biosynthesis and Enzymology of Antifungal Natural Products - R01AI141481R01AI141481 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K, HOUK, KENDALL N · 2019 to 2023
$2.8M
Total Synthesis of Bioactive Indole AlkaloidsF31GM117945 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PICAZO, ELIAS · 2016 to 2018
$93k
NIAID NIH HHS R01 AI141481NIGMS NIH HHS F31 GM117945
6 · The paper itself

Abstract

An ongoing challenge in chemical research is to design catalysts that select the outcomes of the reactions of complex molecules. Chemists rely on organocatalysts or transition metal catalysts to control stereoselectivity, regioselectivity and periselectivity (selectivity among possible pericyclic reactions). Nature achieves these types of selectivity with a variety of enzymes such as the recently discovered pericyclases-a family of enzymes that catalyse pericyclic reactions

Indexed as

BiocatalysisCycloaddition ReactionAspergillusBiological ProductsCatalytic DomainEnzymesModels, MolecularBiological ProductsEnzymes

Identifiers

PMID32999480
PMCPMC7534572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.