ArticleNature2020
Negative feedback control of neuronal activity by microglia.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 561 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
561citing papers in PubMed, 2 pooled it
49.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
561 citing papers in PubMed, 2 syntheses or guidelines pooled it, 958 citations in OpenAlex.
- Identification of suicide brain transcriptomic signatures using meta-analysis of multiple cohorts.Translational psychiatry · 2026Pooled it
- A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders.Journal of neuroinflammation · 2025Pooled it
- Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea.Glia · 2026Article
- Sex-specific role of microglia in ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Targeting glial PD-1/PD-L1 restores microglial homeostasis and reduces neuronal hyperactivity in an Alzheimer's disease model.Science advances · 2026Article
- Nonsurgical Platelet Membrane-Decorated Gold Yarnball Brain Antenna for In Situ Nitric Oxide Generation and Neuronal Regeneration.ACS nano · 2026Article
- Microglia stabilize sleep homeostasis via adenosine AScience advances · 2026Article
- Review
- cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy.Nature neuroscience · 2026Article
- Purinergic signaling in osteoarthritis: Mechanistic insights into pathogenesis and therapeutic targeting.Genes & diseases · 2026Review
- Immune-mediated excitotoxicity in brain disorders.Nature reviews. Immunology · 2026Review
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- Human-specific SRGAP2 paralogs synchronize neotenic microglial maturation and synaptic development.Neuron · 2026Article
- Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling.Cell metabolism · 2026Article
- A nonsurgical brain implant enabled through a cell-electronics hybrid for focal neuromodulation.Nature biotechnology · 2026Article
- Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026Review
- Microglia extract neuronal proteolytic organelles via skoupocytosis.bioRxiv : the preprint server for biology · 2026Article
- Article
- Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity.bioRxiv : the preprint server for biology · 2026Article
501 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 12 institutions in 2 countries.
Ana BadimonNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hayley J StrasburgerNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pinar AyataNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-7621-832X
Xinhong ChenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0003-0408-0813
Aditya NairDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-5242-5527
Ako IkegamiDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Philip HwangNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew T ChanNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Steven M GravesDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
Joseph O UweruCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Carola LedderoseDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Munir Gunes KutluDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Michael A WheelerAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anat KahanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Masago IshikawaNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ying-Chih WangDepartment of Genetics and Genomic Sciences, Icahn Institute of Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yong-Hwee E LohNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jean X JiangDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA.
D James SurmeierDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-6376-5225
Simon C RobsonDepartment of Anesthesia, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6374-0194
Wolfgang G JungerDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Robert SebraDepartment of Genetics and Genomic Sciences, Icahn Institute of Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Erin S CalipariDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4723-0623
Paul J KennyNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ukpong B EyoCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5222-4987
Francisco J QuintanaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hiroaki WakeDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Viviana GradinaruDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-5868-348X
Anne SchaeferNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. anne.schaefer@mssm.edu.ORCID http://orcid.org/0000-0002-1051-3710
Icahn School of Medicine at Mount Sinai · USCalifornia Institute of Technology · USBeth Israel Deaconess Medical Center · USNagoya University · JPUniversity of Virginia · USVanderbilt University · USBrigham and Women's Hospital · USBroad Institute · USNorthwestern University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Minnesota · USWashington University in St. Louis · US
Funding
Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Anne Schaefer · 2019 to 2026
$16.5MTherapeutic assessment of synthetic heparin sulfates in transplantation modelsP01HL107152 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI DESAI, UMESH RAMANLAL · 2011 to 2017
$15.8MInstitutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3MResearch Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1MGenomic approach to identification of microglial networks involved in Alzheimer’s disease riskU01AG058635 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOATE, ALISON M · 2018 to 2022
$4.8MTranslational Immunology Training ProgramT32AI078892 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Karen Leigh Edelblum, SERGIO A. LIRA · 2008 to 2026
$4.5MThromboregulatory strategies to prolong xenograft survival.U01AI066331 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROBSON, SIMON C. · 2005 to 2009
$4.1MRole of AHR in Dendritic Cells in the Control of the CNS AutoimmunityR01ES025530 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI Francisco J. Quintana · 2016 to 2026
$3.7MAge-dependent activation of microglia inflammatory state and its epigenetic modulationRF1AG068558 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE, TARAKHOVSKY, ALEXANDER · 2020 to 2020
$3.0MResearch Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0MCognate microglia-neuron interaction and its role in inflammationDP2MH100012 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE · 2012 to 2012
$2.5MPurinergic regulation of T cellsR01GM051477 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JUNGER, WOLFGANG G · 2003 to 2016
$2.5MNCATS NIH HHS KL2 TR002245NCI NIH HHS T32 CA207021NHLBI NIH HHS P01 HL107152NHLBI NIH HHS R01 HL094400NIAID NIH HHS R01 AI126880NIAID NIH HHS T32 AI078892NIAID NIH HHS U01 AI066331NIA NIH HHS F31 AG074652NIA NIH HHS R01 AG045040NIA NIH HHS RF1 AG068558NIA NIH HHS T32 AG049688NIA NIH HHS U01 AG058635NICHD NIH HHS R01 HD098363NICHD NIH HHS U54 HD083211NIDA NIH HHS DP1 DA048931NIDA NIH HHS K99 DA042111NIDA NIH HHS P01 DA047233NIDA NIH HHS R00 DA042111NIEHS NIH HHS R01 ES025530NIGMS NIH HHS R01 GM051477NIGMS NIH HHS R01 GM116162NIGMS NIH HHS R29 GM051477NIGMS NIH HHS R35 GM136429NIMH NIH HHS DP2 MH100012NIMH NIH HHS R01 MH118329NIMH NIH HHS R21 MH115353NIMH NIH HHS RF1 MH117069NINDS NIH HHS K99 NS114111NINDS NIH HHS R01 NS091574NINDS NIH HHS R01 NS102807NINDS NIH HHS R01 NS106721
Abstract
Microglia, the brain's resident macrophages, help to regulate brain function by removing dying neurons, pruning non-functional synapses, and producing ligands that support neuronal survival
Indexed as
Feedback, PhysiologicalNeural Inhibition5'-NucleotidaseAction PotentialsAdenosineAdenosine MonophosphateAdenosine TriphosphateAnimalsAntigens, CDApyraseCalciumCorpus StriatumFemaleHumansMaleMice5'-NucleotidaseAdenosineAdenosine MonophosphateAdenosine TriphosphateAntigens, CDApyraseCalciumCD39 antigenReceptor, Adenosine A1Receptor, Muscarinic M3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.