ArticleNature2020
Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 140 citations in OpenAlex.
- A novel circSLIT2-encoded SLIT2 isoform suppresses neural invasion in gastric cancer.Oncogene · 2026Article
- An interpretable multi-task whole-slide histopathology AI model for non-small cell lung cancer: Cross-cohort generalisation, spatial attention-transcriptomic integration, and molecular-immune profiling.Clinical and translational medicine · 2026Article
- Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single-Cell Resolution.Cell proliferation · 2026Article
- NAT10/acProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Identification and validation of serum SLIT1 as a biomarker for predicting anti-PD-1/PD-L1 resistance in non-small cell lung cancer.Biological procedures online · 2026Article
- Tumour-associated high endothelial venules drive portal-specific immune evasion in lymph nodes via ALOX12.Nature communications · 2026Article
- Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1.Cancer research · 2026Article
- CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Frizzled-1 amplification promotes fibrosis in the gastric tumor microenvironment through the activation of fibroblasts via the SLIT2/ROBO1 axis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Targeting sensory nerves in the tumor microenvironment: a new vulnerability in cancer therapy.Cell communication and signaling : CCS · 2026Review
- Targeting the tripartite axis of immune-metabolic-spatial crosstalk to overcome therapy resistance in breast cancer.Frontiers in immunology · 2026Review
- MiR-19b-3p facilitates colorectal cancer metastasis by mediating the crosstalk between tumor-associated endothelial cells and malignant cells.Frontiers in oncology · 2026Article
- Peripheral nerve remodeling in the tumor microenvironment: neuro-immune crosstalk, molecular mechanisms, and precision therapeutic.Frontiers in immunology · 2026Review
- Discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axisRSC medicinal chemistry · 2025Article
- 3D bioprinting innovations: a new frontier in breast cancer research.Medical oncology (Northwood, London, England) · 2025Review
- Molecular characterization of endosomal self RNA Rmrp-engaged TLR3 dimerization to prime innate activation.Cell research · 2025Article
- Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation.The Journal of clinical investigation · 2025Article
- SLIT2 modulates NMIIA to regulate mitophagy and suppress hepatocellular carcinoma progression.BMC cancer · 2025Article
- Bioengineering a Patient-Derived Vascularized Lung Tumor-on-Chip Model to Decipher Immunomodulation by the Endothelium.Advanced healthcare materials · 2025Article
- Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor-Stroma Ratio and Promote Cancer Progression.Cancer research · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Bernardo TavoraLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Tobias Mederer *Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Kai J Wessel *Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Simon RuffingLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-8660-3635
Mahan SadjadiLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-9729-5199
Marc MissmahlLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Benjamin N OstendorfLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-4492-9252
Xuhang LiuLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Ji-Young KimLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.
Olav OlsenLaboratory of Brain Development and Repair, The Rockefeller University, New York, NY, USA.
Alana L WelmDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9648-8949
Sohail F TavazoieLaboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA. stavazoie@rockefeller.edu.ORCID http://orcid.org/0000-0002-4966-9018
Rockefeller University · USUniversity of California, San Francisco · USUniversity of Utah · US
Funding
An antisense RNA-mediated regulatory program that drives cancer metastasisR01CA240984 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOODARZI, HANI · 2019 to 2023
$2.5MTargeted regulation of transcript stability through RNA methylation and intron retentionR01GM123977 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOODARZI, HANI · 2017 to 2021
$2.0MRegulation of metastatic progression by an endothelial-derived factorR01CA236954 · NCI · ROCKEFELLER UNIVERSITY · PI TAVAZOIE, SOHAIL F. · 2019 to 2022
$1.9MHoward Hughes Medical InstituteNCI NIH HHS R01 CA236954NCI NIH HHS R01 CA240984NIGMS NIH HHS R01 GM123977NIH HHS R01-CA236954-01A1NIH HHS R01CA24098
Abstract
Blood vessels support tumours by providing nutrients and oxygen, while also acting as conduits for the dissemination of cancer
Indexed as
Neoplasm MetastasisAnimalsBreast NeoplasmsChemotaxisDisease Models, AnimalDisease ProgressionEndothelial CellsEndotheliumFemaleHumansIntercellular Signaling Peptides and ProteinsLung NeoplasmsMaleMiceNerve Tissue ProteinsReceptors, ImmunologicIntercellular Signaling Peptides and ProteinsNerve Tissue ProteinsReceptors, ImmunologicRNA, Double-StrandedRoundabout ProteinsSlit Homolog 2 ProteinToll-Like Receptor 3
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.