ArticleCommunications biology2020
Regulatory gene function handoff allows essential gene loss in mosquitoes.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Molecular and Functional Divergence of Zebrafish Sox Paralogs Controlling Endoderm Formation and Left-Right Patterning.Genome biology and evolution · 2025Article
- Article
- Arthropod Pax Gene Evolution: A Role for Vanessa Cardui Twin of Eyeless in Eye Development.Molecular biology and evolution · 2025Article
- Effective target genes for RNA interference-based management of the cabbage stem flea beetle.Insect molecular biology · 2025Article
- A hybrid machine learning model with attention mechanism and multidimensional multivariate feature coding for essential gene prediction.BMC biology · 2025Article
- Recent approaches lead to a deeper understanding of diverse segmentation mechanisms in insects, with a focus on the pair-rule genes.Current opinion in insect science · 2025Review
- Same rule, different genes:Science advances · 2024Article
- Distinct developmental patterns in Anopheles stephensi organ systems.Developmental biology · 2024Article
- Lepidopteran prolegs are novel traits, not leg homologs.Science advances · 2023Article
- Anterior-posterior patterning of segments in Anopheles stephensi offers insights into the transition from sequential to simultaneous segmentation in holometabolous insects.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA.G3 (Bethesda, Md.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Regulatory genes are often multifunctional and constrained, which results in evolutionary conservation. It is difficult to understand how a regulatory gene could be lost from one species' genome when it is essential for viability in closely related species. The gene paired is a classic Drosophila pair-rule gene, required for formation of alternate body segments in diverse insect species. Surprisingly, paired was lost in mosquitoes without disrupting body patterning. Here, we demonstrate that a paired family member, gooseberry, has acquired paired-like expression in the malaria mosquito Anopheles stephensi. Anopheles-gooseberry CRISPR-Cas9 knock-out mutants display pair-rule phenotypes and alteration of target gene expression similar to what is seen in Drosophila and beetle paired mutants. Thus, paired was functionally replaced by the related gene, gooseberry, in mosquitoes. Our findings document a rare example of a functional replacement of an essential regulatory gene and provide a mechanistic explanation of how such loss can occur.
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Registered trials
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