ArticleThe ISME journal2021
Direct interactions with commensal streptococci modify intercellular communication behaviors of Streptococcus mutans.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- ThemBio · 2026Article
- AJournal of bacteriology · 2026Review
- Influence of cell-cell distance on the ecology and evolution of microbial communities.The ISME journal · 2026Review
- Photodynamic therapy for caries management: mechanisms, applications, and perspectives.Frontiers in cellular and infection microbiology · 2026Review
- A strain ofApplied and environmental microbiology · 2025Article
- A Strain ofbioRxiv : the preprint server for biology · 2024Article
- Human saliva modifies growth, biofilm architecture, and competitive behaviors of oral streptococci.mSphere · 2024Article
- SMU_1361c regulates the oxidative stress response ofApplied and environmental microbiology · 2024Article
- Transcriptome Reveals Regulation of Quorum Sensing ofFoods (Basel, Switzerland) · 2024Article
- Social networking at the microbiome-host interface.Infection and immunity · 2023Review
- Growth with Commensal Streptococci AltersJournal of dental research · 2023Article
- mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study.AMB Express · 2023Article
- Quorum Sensing and Quorum Quenching with a Focus on Cariogenic and Periodontopathic Oral Biofilms.Microorganisms · 2022Review
- Evaluation of L-arginine supplement on the growth rate, biofilm formation, and antibiotic susceptibility in Streptococcus mutans.European journal of medical research · 2022Article
- Impact of different oral treatments on the composition of the supragingival plaque microbiome.Journal of oral microbiology · 2022Article
- Complete Genome Sequence of Streptococcus oralis 34.Microbiology resource announcements · 2021Article
- Thermophilin 110 inhibits growth and biofilm formation ofBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Zinc import mediated by AdcABC is critical for colonization of the dental biofilm by Streptococcus mutans in an animal model.Molecular oral microbiology · 2021Article
- Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans.Nature microbiology · 2021Article
- Spatial Correlations and Distribution of Competence Gene Expression in Biofilms ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The formation of dental caries is a complex process that ultimately leads to damage of the tooth enamel from acids produced by microbes in attached biofilms. The bacterial interactions occurring within these biofilms between cariogenic bacteria, such as the mutans streptococci, and health-associated commensal streptococci, are thought to be critical determinants of health and disease. To better understand these interactions, a Streptococcus mutans reporter strain that actively monitors cell-cell communication via peptide signaling was cocultured with different commensal streptococci. Signaling by S. mutans, normally highly active in monoculture, was completely inhibited by several species of commensals, but only when the bacteria were in direct contact with S. mutans. We identified a novel gene expression pattern that occurred in S. mutans when cultured directly with these commensals. Finally, mutant derivatives of commensals lacking previously shown antagonistic gene products displayed wild-type levels of signal inhibition in cocultures. Collectively, these results reveal a novel pathway(s) in multiple health-associated commensal streptococci that blocks peptide signaling and induces a common contact-dependent pattern of differential gene expression in S. mutans. Understanding the molecular basis for this inhibition will assist in the rational design of new risk assessments, diagnostics, and treatments for the most pervasive oral infectious diseases.
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Registered trials
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