ArticleCommunications biology2020
Genetic basis of falling risk susceptibility in the UK Biobank Study.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study.Cell reports. Medicine · 2022Pooled it
- Integrative GWAS Catalog Analysis of Proxy-Trait Intersection in Sarcopenia-Related Musculoskeletal Aging with Multi-Criteria Evidence Integration.Life (Basel, Switzerland) · 2026Article
- Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel.BMC genomics · 2026Article
- Genetic evidence does not support causal associations between brain structures and fall risk: evidence from Mendelian randomization.Brain imaging and behavior · 2026Article
- Associations of Anthropometric Indicators with Bone Mineral Density and the Risk of Bone Fractures and Falls: A Large-Scale Genetic Correlation Study.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Gut microbiota mediates the relationship between smoking and fall risk: A 2-step Mendelian randomization study.Medicine · 2025Article
- Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling.Nature genetics · 2025Article
- The causal link between osteoarthritis and falls: the mediating role of paracetamol.Aging clinical and experimental research · 2025Article
- Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis.JMIR aging · 2025Article
- Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study.Sports medicine and health science · 2025Article
- A causal association between osteoporosis and postural instability: a Mendelian randomization study.Scientific reports · 2025Article
- Sarcopenia, Depressive Symptoms, and Fall Risk: Insights from a National Cohort Study in the Chinese Population.Risk management and healthcare policy · 2025Article
- A causal inference study on the impact of asthma on the onset of chronic obstructive pulmonary disease: two-sample Mendelian randomization.Archives of medical science : AMS · 2025Article
- The impact of bone mineral density on the risk of falling: evidence from genetic correlation and Mendelian randomization analysis.Endocrine · 2024Article
- Variance-components tests for genetic association with multiple interval-censored outcomes.Statistics in medicine · 2024Article
- Falls, fracture and frailty risk in multiple sclerosis: a Mendelian Randomization study to identify shared genetics.Journal of bone and mineral metabolism · 2024Article
- Statin use and fall risk in adults: a cross-sectional survey and mendelian randomization analysis.Frontiers in pharmacology · 2024Article
- Causal associations between genetically determined common psychiatric disorders and the risk of falls: evidence from Mendelian randomization.European journal of medical research · 2023Article
- Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research.Current osteoporosis reports · 2023Review
- The genetics of falling susceptibility and identification of causal risk factors.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Both extrinsic and intrinsic factors predispose older people to fall. We performed a genome-wide association analysis to investigate how much of an individual's fall susceptibility can be attributed to genetics in 89,076 cases and 362,103 controls from the UK Biobank Study. The analysis revealed a small, but significant SNP-based heritability (2.7%) and identified three novel fall-associated loci (P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.