Evidence map›Paper›PMID 32999336›Full record

ArticleScientific reports2020

Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences.

James Maurice, Aaron M Lett, Charlotte Skinner, Alexandra Lim, Matthew Richardson, Ajesh Painadath Thomas, Peter A Summers, Khushi Vyas, Abdul Wadood Tadbier, Ramon Vilar and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

James MauriceDepartment of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, London, W2 1NY, UK.
Aaron M LettDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, W2 1NY, UK.
Charlotte SkinnerDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, W2 1NY, UK.
Alexandra LimDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, W2 1NY, UK.
Matthew RichardsonImperial College Ophthalmology Research Group, Western Eye Hospital, Imperial College London, London, NW1 5QH, UK.
Ajesh Painadath ThomasDepartment of Chemistry, White City Campus, Imperial College London, London, W12 0BZ, UK.
Peter A SummersDepartment of Chemistry, White City Campus, Imperial College London, London, W12 0BZ, UK.
Khushi VyasThe Hamlyn Centre, Institute of Global Health Innovation, South Kensington, Imperial College London, London, SW7 2AZ, UK.
Abdul Wadood TadbierDepartment of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, London, W2 1NY, UK.
Ramon VilarDepartment of Chemistry, White City Campus, Imperial College London, London, W12 0BZ, UK.
Marina K KuimovaDepartment of Chemistry, White City Campus, Imperial College London, London, W12 0BZ, UK.
Serge MiodragovicImperial College Ophthalmology Research Group, Western Eye Hospital, Imperial College London, London, NW1 5QH, UK.
Nikhil VergisDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, W2 1NY, UK.
Paul KellyBlizard Institute, Queen Mary University of London, London, E1 2AT, UK.
Maria Francesca CordeiroImperial College Ophthalmology Research Group, Western Eye Hospital, Imperial College London, London, NW1 5QH, UK.
Jonathan HoareDepartment of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, London, W2 1NY, UK.
Ara DarziDepartment of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, London, W2 1NY, UK.
Robert GoldinDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, W2 1NY, UK.
Mark ThurszDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, W2 1NY, UK.
Alex J ThompsonDepartment of Surgery & Cancer, St. Mary's Hospital Campus, Imperial College London, London, W2 1NY, UK. alex.thompson08@imperial.ac.uk.
Imperial College London · GBSt Mary's Hospital · GBUniversity of Zambia · ZMWestern Eye Hospital · GB

Funding

Department of Health
6 · The paper itself

Abstract

Gastro-intestinal function plays a vital role in conditions ranging from inflammatory bowel disease and HIV through to sepsis and malnutrition. However, the techniques that are currently used to assess gut function are either highly invasive or unreliable. Here we present an alternative, non-invasive sensing modality for assessment of gut function based on fluorescence spectroscopy. In this approach, patients receive an oral dose of a fluorescent contrast agent and a fibre-optic probe is used to make fluorescence measurements through the skin. This provides a readout of the degree to which fluorescent dyes have permeated from the gut into the blood stream. We present preliminary results from our first measurements in human volunteers demonstrating the potential of the technique for non-invasive monitoring of multiple aspects of gastro-intestinal health.

Indexed as

Contrast MediaFluorescent DyesGastrointestinal TractHumansInflammatory Bowel DiseasesSpectrometry, FluorescenceContrast MediaFluorescent Dyes

Identifiers

PMID32999336
PMCPMC7527451
OpenAlexW3091240809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.