Evidence map›Paper›PMID 32999331›Full record

ArticleScientific reports2020

Distinct lung microbiota associate with HIV-associated chronic lung disease in children.

Sudha Bhadriraju, Douglas W Fadrosh, Meera K Shenoy, Din L Lin, Kole V Lynch, Kathryn McCauley, Rashida A Ferrand, Edith D Majonga, Grace McHugh, Laurence Huang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Sudha Bhadriraju *Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital and Trauma Center, University of California San Francisco, 1001 Potrero Avenue, Rm 5K1, San Francisco, CA, 94110-0111, USA.
Douglas W Fadrosh *Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, USA.
Meera K ShenoyDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, USA.
Din L LinDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, USA.
Kole V LynchDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, USA.
Kathryn McCauleyDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, USA.
Rashida A FerrandBiomedical Research and Training Institute, Harare, Zimbabwe.
Edith D MajongaBiomedical Research and Training Institute, Harare, Zimbabwe.
Grace McHughBiomedical Research and Training Institute, Harare, Zimbabwe.
Laurence HuangDivision of Pulmonary and Critical Care Medicine, San Francisco General Hospital and Trauma Center, University of California San Francisco, 1001 Potrero Avenue, Rm 5K1, San Francisco, CA, 94110-0111, USA.
Susan V Lynch *Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, USA.
John Z Metcalfe *Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital and Trauma Center, University of California San Francisco, 1001 Potrero Avenue, Rm 5K1, San Francisco, CA, 94110-0111, USA. john.metcalfe@ucsf.edu.
University of California, San Francisco · USBiomedical Research and Training Institute · ZWSan Francisco General Hospital · USLondon School of Hygiene & Tropical Medicine · GB

Funding

MUTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007185 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle, LAURENCE HUANG · 1985 to 2026
$24.6M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) StudyR01HL143998 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTENSON, STEPHANIE A, HUANG, LAURENCE · 2019 to 2022
$3.2M
Patient-Oriented Research and Mentoring in PneumocystisK24HL087713 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2006 to 2018
$1.8M
Improving Early Identification of Drug Resistant Tuberculosis in HIV Prevalent SeK23AI094251 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI METCALFE, JOHN ZAPATA · 2011 to 2015
$625k
NHLBI NIH HHS K24 HL087713NHLBI NIH HHS R01 HL143998NHLBI NIH HHS T32 HL007185NIAID NIH HHS K23 AI094251Wellcome Trust 206316/Z/17/Z
6 · The paper itself

Abstract

Chronic lung disease (CLD) is a common co-morbidity for HIV-positive children and adolescents on antiretroviral therapy (ART) in sub-Saharan Africa. In this population, distinct airway microbiota may differentially confer risk of CLD. In a cross-sectional study of 202 HIV-infected children aged 6-16 years in Harare, Zimbabwe, we determined the association of sputum microbiota composition (using 16S ribosomal RNA V4 gene region sequencing) with CLD defined using clinical, spirometric, or radiographic criteria. Forty-two percent of children were determined to have CLD according to our definition. Dirichlet multinomial mixtures identified four compositionally distinct sputum microbiota structures. Patients whose sputum microbiota was dominated by Haemophilus, Moraxella or Neisseria (HMN) were at 1.5 times higher risk of CLD than those with Streptococcus or Prevotella (SP)-dominated microbiota (RR = 1.48, p = 0.035). Cell-free products of HMN sputum microbiota induced features of epithelial disruption and inflammatory gene expression in vitro, indicating enhanced pathogenic potential of these CLD-associated microbiota. Thus, HIV-positive children harbor distinct sputum microbiota, with those dominated by Haemophilus, Moraxella or Neisseria associated with enhanced pathogenesis in vitro and clinical CLD.

Indexed as

MicrobiotaAdolescentChildCross-Sectional StudiesFemaleHIV InfectionsHumansLungLung DiseasesMaleSputumZimbabwe

Identifiers

PMID32999331
PMCPMC7527458
OpenAlexW3090365248

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.