ArticleScientific reports2020
Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Nano-Enabled Microfluidic Platforms for Functional Immunomonitoring in Pediatric Sepsis.International journal of nanomedicine · 2026Review
- Exploring treatment effects and fluid resuscitation strategies in septic shock: a deep learning-based causal inference approach.Scientific reports · 2025Article
- The pivotal role of immune functional assays in deciphering immune function alterations.Clinical and experimental immunology · 2025Article
- Hyper-inflammatory profile and immunoparalysis in patients with severe Legionnaires' disease.Frontiers in cellular and infection microbiology · 2023Article
- Peripheral blood mononuclear cell phenotype and function are maintained after overnight shipping of whole blood.Scientific reports · 2022Article
- Individualized resuscitation strategy for septic shock formalized by finite mixture modeling and dynamic treatment regimen.Critical care (London, England) · 2021Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
The complexity of sepsis pathophysiology hinders patient management and therapeutic decisions. In this proof-of-concept study we characterised the underlying host immune response alterations using a standardised immune functional assay (IFA) in order to stratify a sepsis population. In septic shock patients, ex vivo LPS and SEB stimulations modulated, respectively, 5.3% (1/19) and 57.1% (12/21) of the pathways modulated in healthy volunteers (HV), highlighting deeper alterations induced by LPS than by SEB. SEB-based clustering, identified 3 severity-based groups of septic patients significantly different regarding mHLA-DR expression and TNFα level post-LPS, as well as 28-day mortality, and nosocomial infections. Combining the results from two independent cohorts gathering 20 HV and 60 patients, 1 cluster grouped all HV with 12% of patients. The second cluster grouped 42% of patients and contained all non-survivors. The third cluster grouped 46% of patients, including 78% of those with nosocomial infections. The molecular features of these clusters indicated a distinctive contribution of previously described genes defining a "healthy-immune response" and a "sepsis-related host response". The third cluster was characterised by potential immune recovery that underlines the possible added value of SEB-based IFA to capture the sepsis immune response and contribute to personalised management.
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Registered trials
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