SynthesisScientific reports2020
Functional parcellation of the default mode network: a large-scale meta-analysis.
Synthesis in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tasks activating the default mode network map multiple functional systems.Brain structure & function · 2022Pooled it
- Obesity is associated with reduced orbitofrontal cortex volume: A coordinate-based meta-analysis.NeuroImage. Clinical · 2020Pooled it
- PCC-hippocampal functional connectivity associated with stress biomarker changes after meditation training for healthy adults.Neuroscience letters · 2025Trial
- Mechanisms of Repetitive Transcranial Magnetic Stimulation on Post-stroke Depression: A Resting-State Functional Magnetic Resonance Imaging Study.Brain topography · 2022Trial
- Temporal neural dynamics patterns in episodic and chronic migraine: a magnetoencephalography study.The journal of headache and pain · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Mind-Body Interventions as Modulators of Neural Connectivity and Cognition in Individuals at Risk for Alzheimer's Disease: A Systematic Review.Annals of neurosciences · 2026Review
- Cross-atlas Identification of Narrative Hubs via Multi-embedding Graph Models in fMRI Data.Neuroinformatics · 2026Article
- Explicitly nonlinear fMRI networks reveal hidden trajectories of infant brain development.bioRxiv : the preprint server for biology · 2026Article
- Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis.Autism research : official journal of the International Society for Autism Research · 2026Article
- Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- DMN function changes on resting state fMRI in perimenopausal women.Open medicine (Warsaw, Poland) · 2026Article
- Development of areal-level individualized homologous functional parcellations in youth.Communications biology · 2025Article
- Neural Processes Linking Interoception to Moral Preferences Aligned with Group Consensus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.Biology · 2025Review
- Task-based neural correlates of self-focused attention associated with cognitive behavioral therapy response.Biological psychology · 2025Article
- A specific model of resting-state functional brain network in MRI-negative temporal lobe epilepsy.Heliyon · 2025Article
- Individual differences in wellbeing are supported by separable sets of co-active self- and visual-attention-related brain networks.Scientific reports · 2025Article
- Tension-type headache patients' brain responses to instant acupuncture stimulation: a functional magnetic resonance imaging study.Frontiers in neurology · 2025Article
- Advances in Neuroimaging of Breast Cancer Pain: An Overview.Journal of pain research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The default mode network (DMN) consists of several regions that selectively interact to support distinct domains of cognition. Of the various sites that partake in DMN function, the posterior cingulate cortex (PCC), temporal parietal junction (TPJ), and medial prefrontal cortex (MPFC) are frequently identified as key contributors. Yet, it remains unclear whether these subcomponents of the DMN make unique contributions to specific cognitive processes and health conditions. To address this issue, we applied a meta-analytic parcellation approach used in prior work. This approach used the Neurosynth database and classification methods to quantify the association between PCC, TPJ, and MPFC activation and specific topics related to cognition and health (e.g., decision making and smoking). Our analyses replicated prior observations that the PCC, TPJ, and MPFC collectively support multiple cognitive functions such as decision making, memory, and awareness. To gain insight into the functional organization of each region, we parceled each region based on its coactivation pattern with the rest of the brain. This analysis indicated that each region could be further subdivided into functionally distinct subcomponents. Taken together, we further delineate DMN function by demonstrating the relative strengths of association among subcomponents across a range of cognitive processes and health conditions. A continued attentiveness to the specialization within the DMN allows future work to consider the nuances in sub-regional contributions necessary for healthy cognition, as well as create the potential for more targeted treatment protocols in various health conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.