Evidence map›Paper›PMID 32999305›Full record

ArticleScientific reports2020

Effects of an early life diet containing large phospholipid-coated lipid globules on hepatic lipid metabolism in mice.

Onne A H O Ronda, Bert J M van de Heijning, Ingrid Martini, Albert Gerding, Justina C Wolters, Ydwine T van der Veen, Martijn Koehorst, Angelika Jurdzinski, Rick Havinga, Eline M van der Beek and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Onne A H O RondaDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands.
Bert J M van de HeijningDanone Nutricia Research, Uppsalalaan 12, 3584CT, Utrecht, The Netherlands.
Ingrid MartiniLaboratory Medicine, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700RB, Groningen, The Netherlands.
Albert GerdingLaboratory Medicine, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700RB, Groningen, The Netherlands.
Justina C WoltersDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands.
Ydwine T van der VeenDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands.
Martijn KoehorstDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands.
Angelika JurdzinskiDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands.
Rick HavingaDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands.
Eline M van der BeekDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands.
Folkert KuipersDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands.
Henkjan J VerkadeDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, CA31, PO Box 30001, 9700 RB, Groningen, The Netherlands. h.j.verkade@umcg.nl.
University Medical Center Groningen · NLUniversity of Groningen · NLDanone (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently reported that feeding mice in their early life a diet containing a lipid structure more similar to human milk (eIMF, Nuturis) results in lower body weights and fat mass gain upon high fat feeding in later life, compared to control (cIMF). To understand the underlying mechanisms, we now explored parameters possibly involved in this long-term effect. Male C57BL/6JOlaHsd mice, fed rodent diets containing eIMF or cIMF from postnatal (PN) day 16-42, were sacrificed at PN42. Hepatic proteins were measured using targeted proteomics. Lipids were assessed by LC-MS/MS (acylcarnitines) and GC-FID (fatty-acyl chain profiles). Early life growth and body composition, cytokines, and parameters of bile acid metabolism were similar between the groups. Hepatic concentrations of multiple proteins involved in β-oxidation (+ 17%) the TCA cycle (+ 15%) and mitochondrial antioxidative proteins (+ 28%) were significantly higher in eIMF versus cIMF-fed mice (p < 0.05). Hepatic L-carnitine levels, required for fatty acid uptake into the mitochondria, were higher (+ 33%, p < 0.01) in eIMF-fed mice. The present study indicates that eIMF-fed mice have higher hepatic levels of proteins involved in fatty acid metabolism and oxidation. We speculate that eIMF feeding programs the metabolic handling of dietary lipids.

Indexed as

AnimalsBody CompositionChromatography, LiquidDietary FatsDiet, High-FatFatty AcidsHumansLipid MetabolismLiverMaleMiceMice, Inbred C57BLMilk, HumanObesityPhospholipidsTandem Mass SpectrometryDietary FatsFatty AcidsPhospholipids

Identifiers

PMID32999305
PMCPMC7527984
OpenAlexW3090127935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.