Evidence map›Paper›PMID 32999271›Full record

ArticleSpinal cord series and cases2020

Spinal cord dysfunction after COVID-19 infection.

Gianluca Sampogna, Noemi Tessitore, Tatiana Bianconi, Alessandra Leo, Michele Zarbo, Emanuele Montanari, Michele Spinelli

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Spinal cord series and cases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  7. Spinal cord involvement in COVID-19: A review.The journal of spinal cord medicine · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gianluca SampognaUnipolar Spinal Unit and Neurourology Service, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Noemi TessitoreUnipolar Spinal Unit and Neurourology Service, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Tatiana BianconiUnipolar Spinal Unit and Neurourology Service, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Alessandra LeoUnipolar Spinal Unit and Neurourology Service, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Michele ZarboUnipolar Spinal Unit and Neurourology Service, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Emanuele MontanariUnit of Urology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.
Michele SpinelliUnipolar Spinal Unit and Neurourology Service, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy. michele.spinelli@ospedaleniguarda.it.ORCID http://orcid.org/0000-0002-6245-0205
University of Milan · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe observed individuals affected by spinal cord dysfunction (SCD) after coronavirus disease 2019 (COVID-19). The aim of our report is to provide our initial experience with individuals experiencing SCD after COVID-19 in a referral center in Northern Italy, from February 21 to July 15, 2020. CASE PRESENTATION: We report on three men with SCD after COVID-19. Case 1, aged 69 years, experienced T10 AIS B paraplegia upon awakening due to spinal cord ischemia from T8 to conus medullaris, besides diffuse thromboses, 27 days after the onset of COVID-19 symptoms. Case 2, aged 56 years, reported progressive cervicalgia 29 days after COVID-19 onset associated with C3 AIS C tetraplegia. Magnetic resonance imaging (MRI) revealed a C4-C6 spinal epidural abscess (SEA) requiring a C3-C4 left hemilaminectomy. Case 3, aged 48 years, reported backache together with lower limb muscle weakness on day 16 after being diagnosed with COVID-19. Exam revealed T2 AIS A paraplegia and an MRI showed a T1-T7 SEA. He underwent a T3-T4 laminectomy. Prior to SCD, all three individuals suffered from respiratory failure due to COVID-19, required mechanical ventilation, had cardiovascular risk factors, experienced lymphopenia, and received tocilizumab (TCZ). DISCUSSION: To our knowledge, this is the first report of SCD after COVID-19. Based on our experience, we did not observe a direct viral infection, but there were two different etiologies. In Case 1, the individual developed spinal cord ischemia, whereas in Cases 2 and 3 SEAs were likely related to the use of TCZ used to treat COVID-19.

Indexed as

BetacoronavirusAgedCoronavirus InfectionsCOVID-19HumansLaminectomyMaleMiddle AgedPandemicsPneumonia, ViralSARS-CoV-2Spinal CordSpinal Cord Diseases

Identifiers

PMID32999271
PMCPMC7525226
OpenAlexW3091453706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.