Evidence map›Paper›PMID 32999227›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy.

Michiru Sawahata, Yasumaro Fujiki, Naomi Nakano, Mamitaro Ohtsuki, Tetsuo Yamaguchi, Keisuke Uchida, Yoshinobu Eishi, Takuji Suzuki, Koichi Hagiwara, Masashi Bando

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Potential Association ofMicroorganisms · 2023
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Michiru SawahataDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
Yasumaro FujikiDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
Naomi NakanoDepartment of Dermatology, Jichi Medical University, Japan.
Mamitaro OhtsukiDepartment of Dermatology, Jichi Medical University, Japan.
Tetsuo YamaguchiShinjuku Tsurukame Clinic, Japan.
Keisuke UchidaDivision of Surgical Pathology, Tokyo Medical and Dental University Hospital, Japan.
Yoshinobu EishiDepartment of Human Pathology, Tokyo Medical and Dental University, Japan.
Takuji SuzukiDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
Koichi HagiwaraDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
Masashi BandoDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
Jichi Medical University · JPTokyo Medical and Dental University · JPTokyo Medical and Dental University Hospital · JP

Funding

Genome edited iPS cell-derived macrophages as a novel lung cell therapyR01HL136721 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SUZUKI, TAKUJI · 2017 to 2020
$1.6M
NHLBI NIH HHS R01 HL136721
6 · The paper itself

Abstract

A 46-year-old woman with uveitis was referred to our respiratory diseases department in July 2018. Her medical history included transient bilateral hilar mediastinal lymphadenopathy (BHL) and multiple pulmonary nodules in May 2013 during pegylated interferon-alpha and ribavirin treatment for chronic hepatitis C infection. Five years post-treatment, chest X-ray revealed BHL and nodular recurrence. A biopsy of the subcutaneous buttock nodules revealed scattered non-caseating epithelioid granulomas with positive PAB immunohistochemical staining. This seem to be the first report of Propionibacterium acnes-associated sarcoidosis possibly initially triggered by interferon-alpha therapy. Understanding the mechanisms underlying interferon-triggered P. acnes-associated sarcoidosis may clarify the sarcoidosis immunopathogenesis.

Indexed as

SarcoidosisSarcoidosis, PulmonaryFemaleHumansInterferon-alphaMiddle AgedNeoplasm Recurrence, LocalPropionibacterium acnesRibavirinInterferon-alphaRibavirinbilateral hilar and mediastinal lymphadenopathydrug-induced sarcoidosis-like reactioninterferonsarcoidosis

Identifiers

PMID32999227
PMCPMC7990622
OpenAlexW3090804797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.