Evidence map›Paper›PMID 32999221›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Giant Hepatomegaly with Spleno-testicular Enlargement in a Patient with Apolipoprotein A-I Amyloidosis: An Uncommon Type of Amyloidosis in Japan.

Tsuneaki Yoshinaga, Nagaaki Katoh, Masahide Yazaki, Mitsuto Sato, Fuyuki Kametani, Hideo Yasuda, Kyohei Watanabe, Kazuhito Kawata, Mayuko Nakagawa, Yoshiki Sekijima

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Tsuneaki YoshinagaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Nagaaki KatohDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Masahide YazakiInstitute for Biomedical Sciences, Shinshu University, Japan.
Mitsuto SatoDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Fuyuki KametaniDepartment of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Japan.
Hideo YasudaFirst Depatment of Medicine, Hamamatsu University School of Medicine, Japan.
Kyohei WatanabeDepartment of Urology, Hamamatsu University Hospital, Japan.
Kazuhito KawataHepatology Division, Department of Internal Medicine II, Hamamatsu University School of Medicine, Japan.
Mayuko NakagawaInstitute for Biomedical Sciences, Shinshu University, Japan.
Yoshiki SekijimaDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Shinshu University · JPHamamatsu University School of Medicine · JPHamamatsu University Hospital · JPTokyo Metropolitan Institute of Medical Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary systemic amyloidosis aside from transthyretin-related familial amyloid polyneuropathy is quite uncommon in Japan. We herein report a sporadic case of hereditary apolipoprotein A-I (apoAI) amyloidosis. The patient was a 43-year-old Japanese man who exhibited marked hepatomegaly with spleno-testicular enlargement. While he was initially thought to have primary AL amyloidosis, a proteomics analysis revealed that the amyloid was composed of variant apoAI with an E34K variant. To date, only one patient with apoAI amyloidosis has been reported in Japan. However, our study suggests that more patients may be present in Japan, and the majority may have been diagnosed with other types of amyloidosis due to its clinical similarity.

Indexed as

Amyloid Neuropathies, FamilialApolipoprotein A-IAdultHepatomegalyHumansJapanMalePrealbuminApolipoprotein A-IPrealbuminApoAI amyloidosishepatic amyloidosishereditary systemic amyloidosisproteomic analysistesticular amyloidosis

Identifiers

PMID32999221
PMCPMC7946490
OpenAlexW3091491622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.