Evidence map›Paper›PMID 32999036›Full record

ArticleJournal of virology2020

Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus.

Amber R Syage, H Atakan Ekiz, Dominic D Skinner, Colleen Stone, Ryan M O'Connell, Thomas E Lane

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Spatial gene expression analysis reveals pathological niches in Japanese encephalitis virus neuroinvasion.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Amber R SyageDivision of Microbiology & Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
H Atakan EkizDivision of Microbiology & Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Dominic D SkinnerDivision of Microbiology & Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Colleen StoneDivision of Microbiology & Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Ryan M O'ConnellDivision of Microbiology & Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Thomas E LaneDivision of Microbiology & Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah, USA tlane@uci.edu.ORCID 0000-0003-0392-0825
University of Utah · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Chemokines and Viral-Induced Neurologic DiseaseR01NS041249 · NINDS · UNIVERSITY OF UTAH · PI LANE, THOMAS E · 2002 to 2019
$5.4M
Defining mechanisms of disease and repair in a viral model of multiple sclerosisR35NS116835 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Thomas E Lane · 2020 to 2026
$5.0M
Micro RNAs and chronic, low-grade inflammationR01AG047956 · NIA · UNIVERSITY OF UTAH · PI O'CONNELL, RYAN M · 2015 to 2019
$1.7M
NCATS NIH HHS UL1 TR002538NIA NIH HHS R01 AG047956NINDS NIH HHS R01 NS041249NINDS NIH HHS R35 NS116835
6 · The paper itself

Abstract

Intracranial (i.c.) infection of susceptible C57BL/6 mice with the neurotropic JHM strain of mouse hepatitis virus (JHMV) (a member of the

Indexed as

AnimalsCentral Nervous System InfectionsComputational BiologyCoronavirus InfectionsEncephalomyelitisGene Expression ProfilingH-2 AntigensHost-Pathogen InteractionsImmunity, InnateMiceMurine hepatitis virusSequence Analysis, RNASingle-Cell AnalysisH-2 Antigenscentral nervous systemcentral nervous system infectionscoronavirushost defenseimmunologyneuroimmunologysingle-cell RNA sequencing

Identifiers

PMID32999036
PMCPMC7925182
OpenAlexW3090177768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.