Evidence map›Paper›PMID 32999032›Full record

ArticleJournal of virology2020

The Tegument Protein pUL47 of Marek's Disease Virus Is Necessary for Horizontal Transmission and Is Important for Expression of Glycoprotein gC.

Aurélien Chuard, Katia Courvoisier-Guyader, Sylvie Rémy, Stephen Spatz, Caroline Denesvre, David Pasdeloup

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  4. mRNA Splicing ofViruses · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Aurélien ChuardLaboratory of Biology of Avian Viruses, INRAE-Université de Tours, UMR1282 ISP, Nouzilly, France.
Katia Courvoisier-GuyaderLaboratory of Biology of Avian Viruses, INRAE-Université de Tours, UMR1282 ISP, Nouzilly, France.
Sylvie RémyLaboratory of Biology of Avian Viruses, INRAE-Université de Tours, UMR1282 ISP, Nouzilly, France.
Stephen SpatzU.S. Department of Agriculture, Agricultural Research Service, U.S. National Poultry Research Center, USDA ARS USNPRC, Athens, Georgia, USA.
Caroline DenesvreLaboratory of Biology of Avian Viruses, INRAE-Université de Tours, UMR1282 ISP, Nouzilly, France caroline.denesvre@inrae.fr david.pasdeloup@inrae.fr.
David PasdeloupLaboratory of Biology of Avian Viruses, INRAE-Université de Tours, UMR1282 ISP, Nouzilly, France caroline.denesvre@inrae.fr david.pasdeloup@inrae.fr.ORCID 0000-0003-3922-4493
Université de Tours · FRAgricultural Research Service · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral tropism and transmission of herpesviruses are best studied in their natural host for maximal biological relevance. In the case of alphaherpesviruses, few reports have focused on those aspects, primarily because of the few animal models available as natural hosts that are compatible with such studies. Here, using Marek's disease virus (MDV), a highly contagious and deadly alphaherpesvirus of chickens, we analyze the role of tegument proteins pUL47 and pUL48 in the whole life cycle of the virus. We report that a virus lacking the UL48 gene (vΔUL48) is impaired in growth in cell culture and has diminished virulence

Indexed as

AnimalsChickensGenes, ViralHerpesvirus 2, GallidMarek DiseaseMutationPoultry DiseasesRNA SplicingSkinViral Envelope ProteinsViral ProteinsViral TropismVirus Replicationglycoprotein gC, herpes simplex virus type 1UL48 protein, Gallid herpesvirus 2Viral Envelope ProteinsViral ProteinsglycoproteinsHerpesviridaeMarek’s disease virustegumenttransmissionUL47

Identifiers

PMID32999032
PMCPMC7944448
OpenAlexW3091278800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.