Evidence map›Paper›PMID 32999027›Full record

ArticleJournal of virology2020

Identification and Characterization of CD4

Hannah Voic, Rory D de Vries, John Sidney, Paul Rubiro, Erin Moore, Elizabeth Phillips, Simon Mallal, Brittany Schwan, Daniela Weiskopf, Alessandro Sette and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Review
  3. Comprehensive mapping of human CD4Cell reports. Medicine · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. PINK1 is a target of T cell responses in Parkinson's disease.bioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Tiza-BMJ open · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Hannah VoicCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Rory D de VriesCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
John SidneyCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Paul RubiroCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Erin MooreCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Elizabeth PhillipsInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.
Simon MallalInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.
Brittany SchwanCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Daniela WeiskopfCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Alessandro Sette *Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Alba Grifoni *Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA agrifoni@lji.org.ORCID 0000-0002-2209-5966
La Jolla Institute for Immunology · USMurdoch University · AU

Funding

Single-cell atlas of lung tissue-resident memory T cells reactive to upper and lower respiratory tract pathogensU19AI118626 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Bjoern Peters · 2015 to 2026
$36.7M
T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2019 to 2026
$32.8M
NIAID NIH HHS U19 AI118626NIAID NIH HHS U19 AI142742
6 · The paper itself

Abstract

Infections with varicella-zoster virus (VZV) are associated with a range of clinical manifestations. Primary infection with VZV causes chicken pox. The virus remains latent in neurons, and it can reactivate later in life, causing herpes zoster (HZ). Two different vaccines have been developed to prevent HZ; one is based on a live attenuated VZV strain (Zostavax), and the other is based on adjuvanted gE recombinant protein (Shingrix). While Zostavax efficacy wanes with age, Shingrix protection retains its efficacy in elderly subjects (individuals 80 years of age and older). In this context, it is of much interest to understand if there is a role for T cell immunity in the differential clinical outcome and if there is a correlate of protection between T cell immunity and Shingrix efficacy. In this study, we characterized the Shingrix-specific

Indexed as

VaccinationAgedAged, 80 and overAntibodies, ViralCD4-Positive T-LymphocytesCell LineEpitopes, T-LymphocyteHerpesvirus 3, HumanHerpes ZosterHerpes Zoster VaccineHumansImmunity, CellularMaleMiddle AgedVaccines, AttenuatedAntibodies, ViralEpitopes, T-LymphocyteHerpes Zoster VaccineVaccines, AttenuatedCD4+ T cellsepitopeHLA restrictionShingrixvaricella-zoster virusVZV

Identifiers

PMID32999027
PMCPMC7925171
OpenAlexW3091490632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.