ArticleScience translational medicine2020
Bicyclic azetidines kill the diarrheal pathogen
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 76 citations in OpenAlex.
- Structure-Activity Relationship Study of Anti-Cryptosporidium Benzoxaboroles Yields Enhanced Potency and Curative Efficacy.Journal of medicinal chemistry · 2026Article
- From conventional to biosensor-based detection ofFood and waterborne parasitology · 2026Review
- Genomic heterogeneity of NAD(P)H dehydrogenase predisposes Cryptosporidium to clofazimine resistance.Nature microbiology · 2026Article
- Insights into the lifecycle of Cryptosporidium and compounds targeting developmental stages.Current opinion in microbiology · 2026Review
- Pathogenicity and virulence ofVirulence · 2025Review
- Article
- Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection.Cell reports · 2025Article
- Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposesbioRxiv : the preprint server for biology · 2025Article
- Improved Bicyclic Pyrrolidine Analogues InhibitJournal of medicinal chemistry · 2025Article
- A propidium iodide-basedAntimicrobial agents and chemotherapy · 2025Article
- Targeting translation initiation yields fast-killing therapeutics against the zoonotic parasite Cryptosporidium parvum.PLoS pathogens · 2025Article
- Discovery of an Orally Efficacious Pyrazolo[3,4-Journal of medicinal chemistry · 2025Article
- Editorial: Chemical-genetics to study microbial pathogen basis of infection and drug targets.Frontiers in cellular and infection microbiology · 2025Article
- Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions.Parasite (Paris, France) · 2025Review
- Multicopy subtelomeric genes underlie animal infectivity of divergent Cryptosporidium hominis subtypes.Nature communications · 2024Article
- Pyridopyrimidinones as a new chemotype of calcium dependent protein kinase 1 (CDPK1) inhibitors for Cryptosporidium.Molecular and biochemical parasitology · 2024Article
- Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis.Nature microbiology · 2024Article
- Article
- Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice.Nature communications · 2024Article
- ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development.iScience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 9 institutions in 4 countries.
Sumiti VinayakDepartment of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.ORCID 0000-0003-4549-6268
Rajiv S JumaniCellular, Molecular and Biomedical Sciences Graduate Program, University of Vermont, Burlington, VT 05405, USA.
Peter MillerDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Muhammad M HasanCellular, Molecular and Biomedical Sciences Graduate Program, University of Vermont, Burlington, VT 05405, USA.
Briana I McLeodDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9103-9397
Jayesh TandelDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8494-6271
Erin E StebbinsDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Jose E TeixeiraDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Julien BorrelChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.ORCID 0000-0003-4045-5256
Arthur GonseChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
Mingliang ZhangInternational Discovery Service Unit, WuXi AppTec (Tianjin) Co. Ltd., Tianjin 300457, P.R. China.ORCID 0000-0003-4099-1462
Xianshui YuInternational Discovery Service Unit, WuXi AppTec (Tianjin) Co. Ltd., Tianjin 300457, P.R. China.ORCID 0000-0003-3670-9970
Amy WernimontStructural Genomics Consortium, MaRS Building, South Tower, 101 College Street, Suite 700, Toronto, Ontario M5G 1L7, Canada.
Chris WalpoleStructural Genomics Consortium, MaRS Building, South Tower, 101 College Street, Suite 700, Toronto, Ontario M5G 1L7, Canada.
Sean EckleyEisai Inc., Cambridge, MA 02140, USA.
Melissa S LoveCalibr, a division of The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-5835-3827
Case W McNamaraCalibr, a division of The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-5754-3407
Manmohan SharmaStructural Parasitology, Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110070, India.
Amit SharmaStructural Parasitology, Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110070, India.
Christina A SchererChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
Nobutaka KatoChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.
Stuart L SchreiberChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.ORCID 0000-0003-1922-7558
Bruno MelilloChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA.ORCID 0000-0002-9708-5287
Boris StriepenDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. striepen@vet.upenn.edu christopher.huston@uvm.edu eamonjcomer@gmail.com.ORCID 0000-0002-7426-432X
Christopher D HustonDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA. striepen@vet.upenn.edu christopher.huston@uvm.edu eamonjcomer@gmail.com.ORCID 0000-0002-5393-139X
Eamon ComerChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA. striepen@vet.upenn.edu christopher.huston@uvm.edu eamonjcomer@gmail.com.ORCID 0000-0002-2989-9801
Broad Institute · USUniversity of Vermont · USUniversity of Pennsylvania · USInternational Centre for Genetic Engineering and Biotechnology · INScripps Research Institute · USStructural Genomics Consortium · CAWuXi AppTec (China) · CNEisai (United States) · USUniversity of Illinois Urbana-Champaign · US
Funding
Genetic Analysis of CryptosporidiumR01AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STRIEPEN, BORIS · 2014 to 2023
$4.2MSexual Development of CryptosporidiumR01AI127798 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STRIEPEN, BORIS · 2017 to 2025
$4.1MGenetic Analysis of CryptosporidiumR37AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BORIS STRIEPEN · 2024 to 2026
$1.5MNovel approaches to develop a treatment for cryptosporidiosisR21AI101381 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUSTON, CHRISTOPHER D · 2013 to 2014
$419kNIAID NIH HHS R01 AI112427NIAID NIH HHS R01 AI127798NIAID NIH HHS R21 AI101381NIAID NIH HHS R37 AI112427
Abstract
PubMed holds no abstract for this paper.
Indexed as
AzetidinesCryptosporidiosisCryptosporidiumParasitesPhenylalanine-tRNA LigaseAnimalsDiarrheaMiceAzetidinesPhenylalanine-tRNA Ligase
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.