ArticleScience translational medicine2020
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Five-year outcomes after surgical treatment of infant postinfectious hydrocephalus in sub-Saharan Africa: results of a randomized trial.Journal of neurosurgery. Pediatrics · 2025Trial
- Assessing the utility of low resolution brain imaging: treatment of infant hydrocephalus.NeuroImage. Clinical · 2021Trial
- Village-level surveillance of neonatal disease with integrated real-time dashboards and quality-control in Uganda.medRxiv : the preprint server for health sciences · 2026Article
- Genome admixture analysis of 1,030 Ugandan infants with neonatal sepsis and hydrocephalus demonstrates geographical stratification of population disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Article
- GLAPAL-H: Global, Local, and Parts Aware Learner for Hydrocephalus Infection Diagnosis in Low-Field MRI.IEEE transactions on bio-medical engineering · 2026Article
- Adeno-associated viruses (AAVs) induce dose-dependent neonatal ventriculomegaly following intracerebroventricular administration.bioRxiv : the preprint server for biology · 2025Article
- Neural Protection Through Health Education: Early Childhood Interventions to Prevent Neurological Conditions Requiring Surgical Care.Children (Basel, Switzerland) · 2025Review
- Evaluation of a Probe-Based Enrichment Protocol for Nanopore Sequencing of Zoonotic Viruses.Viruses · 2025Article
- Poor surgical outcomes following Paenibacillus infant infectious hydrocephalus.Journal of neurosurgery. Pediatrics · 2025Observational
- GLAPAL-H: Global, Local, And Parts Aware Learner for Hydrocephalus Infection Diagnosis in Low-Field MRI.medRxiv : the preprint server for health sciences · 2025Article
- Paediatric hydrocephalus.Nature reviews. Disease primers · 2024Review
- Validation of the VirCapSeq-VERT system for differential diagnosis, detection, and surveillance of viral infections.Journal of clinical microbiology · 2024Article
- Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Brain imaging with portable low-field MRI.Nature reviews bioengineering · 2023Article
- Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study.The Lancet. Microbe · 2023Observational
- Infection diagnosis in hydrocephalus CT images: a domain enriched attention learning approach.Journal of neural engineering · 2023Article
- Febrile sepsis: first report of human disease due toAccess microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
52 authors at 14 institutions in 5 countries.
Joseph N PaulsonDepartment of Biostatistics, Product Development, Genentech Inc., South San Francisco, CA 94080, USA.ORCID 0000-0001-8221-7139
Brent L WilliamsCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-2740-5051
Christine HehnlyInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Nischay MishraCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-1177-9641
Shamim A SinnarCenter for Neural Engineering, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-6625-181X
Lijun ZhangInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0003-4974-2745
Paddy SsentongoCenter for Neural Engineering, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0003-1565-5731
Edith Mbabazi-KabachelorCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.ORCID 0000-0001-7912-7116
Dona S S WijetungeDepartment of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Benjamin von BredowDepartment of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-8924-2193
Ronnie MulondoCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.
Julius KiwanukaDepartment of Pediatrics, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara, Uganda.
Francis BajunirweDepartment of Epidemiology, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.ORCID 0000-0002-1326-5230
Joel BaziraDepartment of Microbiology, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara, Uganda.
Lisa M BebellDivision of Infectious Disease, Massachusetts Genereal Hospital, Harvard Medical School, 55 Fruit St, GRJ-504, Boston, MA 02114, USA.
Kathy BurgoineNeonatal Unit, Department of Paediatrics and Child Health, Mbale Regional Referral Hospital, Plot 29-33 Pallisa Road, P.O. Box 1966, Mbale, Uganda.ORCID 0000-0001-7975-745X
Mara Couto-RodriguezCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-9799-0068
Jessica E EricsonDivision of Pediatric Infectious Disease, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-8765-2065
Tim EricksonCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.ORCID 0000-0003-0058-3309
Matthew FerrariCenter for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-5251-8168
Melissa GladstoneInstitute for Translational Medicine, University of Liverpool, Liverpool, L12 2AP, UK.ORCID 0000-0002-2579-9301
Cheng GuoCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Murali HaranDepartment of Statistics, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0003-4440-8625
Mady HornigDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.ORCID 0000-0001-7572-3092
Albert M IsaacsDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63130, USA.ORCID 0000-0001-8405-2454
Brian Nsubuga KaayaCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.ORCID 0000-0002-6633-6012
Sheila M KangereCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.ORCID 0000-0003-1217-5812
Abhaya V KulkarniDivision of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, M5G 1X8, Canada.ORCID 0000-0002-1706-7004
Elias KumbakumbaDepartment of Pediatrics, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara, Uganda.
Xiaoxiao LiInstitute for Translational Medicine, University of Liverpool, Liverpool, L12 2AP, UK.
David D LimbrickDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63130, USA.ORCID 0000-0001-6557-373X
Joshua MagombeCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.ORCID 0000-0002-5017-0206
Sarah U MortonDivision of Newborn Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0002-7816-2646
John MugambaCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.
James NgCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Peter Olupot-OlupotMbale Clinical Research Institute, Mbale Regional Referral Hospital, Plot 29-33 Pallisa Road, P.O. Box 1966 Mbale, Uganda.
Justin OnenCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.
Mallory R PetersonCenter for Neural Engineering, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-5734-9260
Farrah RoyDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Kathryn SheldonInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-9093-4645
Reid TownsendDepartment of Medicine, Washington University School of Medicine , St. Louis, MO 63130, USA.
Andrew D WeeksSanyu Research Unit, Liverpool Women's Hospital, University of Liverpool, Liverpool L8 7SS, UK.ORCID 0000-0002-1909-337X
Andrew J WhalenDepartment of Mechanical Engineering, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-0782-9300
John QuackenbushDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-2702-5879
Peter SsenyongaCURE Children's Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.
Michael Y GalperinNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-2265-5572
Mathieu AlmeidaUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, 78350, France.ORCID 0000-0003-4971-0049
Hannah AtkinsDepartment of Comparative Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-7689-1477
Benjamin C WarfDepartment of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
W Ian LipkinCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-8768-9386
James R BroachInstitute for Personalized Medicine, Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0003-1197-0312
Steven J SchiffCenter for Neural Engineering, Pennsylvania State University, University Park, PA 16802, USA. steven.j.schiff@gmail.com.
Pennsylvania State University · USCURE Children’s Hospital of Uganda · UGColumbia University · USMbarara University of Science and Technology · UGUniversity of Liverpool · GBHarvard University · USWashington University in St. Louis · USBoston Children's Hospital · USHospital for Sick Children · CAMbale Hospital · UGNational Institutes of Health · USNew York University · USPenn State Milton S. Hershey Medical Center · USUniversité Paris-Saclay · FR
Funding
Comparative Analysis Of Completely Sequenced GenomesZIALM000073 · NLM · NATIONAL LIBRARY OF MEDICINE · PI KOONIN, EUGENE V · 2009 to 2025
$43.1MPredictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious DiseaseR01AI145057 · NIAID · YALE UNIVERSITY · PI SCHIFF, STEVEN J · 2018 to 2022
$8.1MPenn State Institutional Career Development CoreKL2TR002015 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VAN SCOY, LAUREN JODI · 2016 to 2025
$7.8MUnraveling the Complexities of Risk and Mechanism in CancerR35CA220523 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI QUACKENBUSH, JOHN · 2018 to 2024
$6.0MControl of the Neonatal Septisome and Hydrocephalus in sub-Saharan AfricaDP1HD086071 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SCHIFF, STEVEN J · 2015 to 2019
$4.1MCOMPARATIVE ANALYSIS OF COMPLETELY SEQUENCED GENOMESZ01LM000073 · NLM · NATIONAL LIBRARY OF MEDICINE · PI KOONIN, EUGENE V · 1996 to 2008
$1.2MIntramural NIH HHS Z01 LM000073Intramural NIH HHS Z99 LM999999Intramural NIH HHS ZIA LM000073Medical Research Council MR/M017990/1NCATS NIH HHS KL2 TR002015NCI NIH HHS R35 CA220523NIAID NIH HHS R01 AI145057NICHD NIH HHS DP1 HD086071
Abstract
Postinfectious hydrocephalus (PIH), which often follows neonatal sepsis, is the most common cause of pediatric hydrocephalus worldwide, yet the microbial pathogens underlying this disease remain to be elucidated. Characterization of the microbial agents causing PIH would enable a shift from surgical palliation of cerebrospinal fluid (CSF) accumulation to prevention of the disease. Here, we examined blood and CSF samples collected from 100 consecutive infant cases of PIH and control cases comprising infants with non-postinfectious hydrocephalus in Uganda. Genomic sequencing of samples was undertaken to test for bacterial, fungal, and parasitic DNA; DNA and RNA sequencing was used to identify viruses; and bacterial culture recovery was used to identify potential causative organisms. We found that infection with the bacterium
Indexed as
CoinfectionHydrocephalusPaenibacillusAnimalsChildHumansInfantMiceUganda
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.