Evidence map›Paper›PMID 32998896›Full record

ArticleScience advances2020

Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4

Tianzhen He, De Yang, Xiao-Qing Li, Mengmeng Jiang, Md Sahidul Islam, Shaokui Chen, Yibo Chen, Yang Yang, Chon-Kit Chou, Anna L Trivett and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Two-pore channels: going with the flows.Biochemical Society transactions · 2022
    Article
  10. Article
  11. The role of CD4International journal of biological sciences · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Tianzhen HeState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.ORCID 0000-0001-7873-853X
De YangCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD, USA.ORCID 0000-0001-6705-8504
Xiao-Qing LiCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD, USA.ORCID 0000-0002-2449-408X
Mengmeng JiangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.ORCID 0000-0002-9069-0150
Md Sahidul IslamState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
Shaokui ChenState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
Yibo ChenState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
Yang YangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
Chon-Kit ChouState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
Anna L TrivettCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD, USA.ORCID 0000-0001-7143-105X
Joost J OppenheimCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD, USA. xchen@umac.mo oppenhej@mail.nih.gov.ORCID 0000-0003-0271-7921
Xin ChenState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China. xchen@umac.mo oppenhej@mail.nih.gov.ORCID 0000-0002-2628-4027
University of Macau · MOFrederick National Laboratory for Cancer Research · USTianjin Medical University Cancer Institute and Hospital · CN

Funding

CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

CD4

Indexed as

ColitisAnimalsAntigen-Presenting CellsForkhead Transcription FactorsLymphocyte ActivationMiceReceptors, Tumor Necrosis Factor, Type IIT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaForkhead Transcription FactorsFoxp3 protein, mouseReceptors, Tumor Necrosis Factor, Type IITnfrsf1b protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID32998896
PMCPMC7527222
OpenAlexW3091457582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.